PMID: 8996195Jan 1, 1997Paper

Discriminative stimulus effects of zolpidem in pentobarbital-trained subjects: II. Comparison with triazolam and caffeine in humans

The Journal of Pharmacology and Experimental Therapeutics
C R RushJ K Rowlett

Abstract

In the present study, four non-drug-abusing humans were trained to discriminate between a hypnotic dose of pentobarbital, 100 mg, and placebo. After acquiring the pentobarbital-placebo discrimination, a range of doses of zolpidem, triazolam, pentobarbital and caffeine were tested to determine whether they shared discriminative stimulus effects with the training dose of pentobarbital, Zolpidem, a rapid-onset, short-duration, quickly eliminated imidazopyridine hypnotic agent, was tested because its discriminative stimulus effects have been shown to differ from those of classic sedative/hypnotic compounds in rodents, but not in nonhuman primates. Triazolam and caffeine were included as positive and negative controls, respectively. The subject-rated and performance-impairing effects of zolpidem, triazolam, pentobarbital and caffeine were assessed concurrently. These four subjects met the discrimination criterion (> or = 80% correct drug identifications on four consecutive seasions) in 4 to 18 (mean = 8.5) sessions, and the pentobarbital-placebo discrimination was well maintained during a test-of-novel-doses and test-of-novel-drugs phase (i.e., placebo and 100 mg pentobarbital occasioned 0-35% [mean = 17%] and 75-100% [mean = 85%] d...Continue Reading

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