Apr 1, 1976

Discriminative stimulus properties of analgesic drugs: narcotic versus non-narcotic analgesics

Archives Internationales De Pharmacodynamie Et De Thérapie
F C ColpaertP A Janssen


Using a food-reinforced two-lever operant procedure, rats (n=6) were trained to discriminate fentanyl (1.25 mg/kg, p.o., t-60') from solvent (1 ml/100 g B.W., p.o., t-60'). The administration of another narcotic analgesic (pethidine) produced a dose-related generalization with the standard fentanyl treatment; six non-narcotic analygesics (suprofen, acetylsalicylic acid, indomethacin, phenacetin, phenylbutazone, tolmetin) were found not to do so. It is concluded that the ability of drugs to produce analgesia is not a sufficient condition for the drugs to produce the narcotic cue as well.

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Mentioned in this Paper

Analgesics, Non-Narcotic
Discrimination (Process of Differentiation)
Meperidine Hydrochloride
Absence of Pain Sensation

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