PMID: 6137837Jul 1, 1983

Discriminative stimulus properties of buspirone compared to central nervous system depressants in rats

Pharmacology, Biochemistry, and Behavior
J S HendryJ A Rosecrans


Two groups of rats were trained to discriminate either IP buspirone from vehicle or IP oxazepam from vehicle using a two-lever FR-10 schedule of sweetened milk presentation. The discrimination in the buspirone group was difficult to establish due to potent response rate decreasing effects. Oxazepam was a very effective stimulus and the discrimination in the oxazepam group was readily established. Tests with oxazepam and pentobarbital in the buspirone group provided no evidence for generalization of the stimulus properties of buspirone to either drug. Tests with buspirone in the oxazepam group also provided no evidence of generalization to buspirone, although tests with pentobarbital indicated almost complete generalization. Finally buspirone and oxazepam were tested in a group of rats previously trained to discriminate pentobarbital from vehicle. The findings supported the data obtained in the buspirone and oxazepam groups, with no indication of generalization from pentobarbital to buspirone, but with complete generalization to oxazepam. These data suggest that buspirone does not share discriminative stimulus properties which are common to other CNS depressants.


Jan 1, 1985·Psychopharmacology·H S GarchaI P Stolerman
Jan 1, 1989·Psychopharmacology·F Woudenberg, J L Slangen
Jan 1, 1994·Psychopharmacology·D J Sanger, B Zivkovic
Jan 1, 1993·Psychopharmacology·T Wada, N Fukuda
Nov 17, 1987·European Journal of Pharmacology·R YoungG Metcalf
Mar 13, 1990·European Journal of Pharmacology·F Woudenberg, J L Slangen
Oct 1, 1985·Pharmacology, Biochemistry, and Behavior·D P TaylorC P Vandermaelen
Jan 1, 1990·Pharmacology, Biochemistry, and Behavior·J B Kamien, W L Woolverton
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·F Woudenberg, T H Hijzen
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·A Van HestB Olivier
Jan 1, 1987·Pharmacology & Therapeutics·S E File, S Pellow
Jan 1, 1990·Pharmacology & Therapeutics·J S Andrews, D N Stephens
Sep 1, 1987·Journal of Affective Disorders·A OrtizS Gershon
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·L A RibletD L Temple
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·T L Davidson
May 30, 1997·European Journal of Pharmacology·K E Vanover
Feb 1, 1997·Pharmacology, Biochemistry, and Behavior·D E McMillanW C Hardwick
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·J B KamienJ R Hughes
Aug 26, 1998·Pharmacology, Biochemistry, and Behavior·M Li, D E McMillan
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·B J Smith, W K Bickel
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·T S KalininaT A Voronina
Jan 1, 1990·Annals of the New York Academy of Sciences·D P Taylor
Mar 31, 1986·The American Journal of Medicine·A S Eison, D L Temple
Mar 31, 1986·The American Journal of Medicine·J D GriffithG R McKinney
Mar 30, 2001·Journal of Psychopharmacology·H Sánchez, D N Velázquez-Martínez
May 1, 1995·Journal of the Experimental Analysis of Behavior·C R RushR R Griffiths
Nov 1, 1984·Pharmacotherapy·P SkolnickB A Weissman

Related Concepts

Operant Conditioning
Discrimination Learning
Dose-Response Relationship, Drug
August Rats
Self Stimulation
Anti-Anxiety Effect

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.