PMID: 2567029Jan 1, 1989

Discriminative stimulus properties of midazolam: comparison with other benzodiazepines

Psychopharmacology
F Woudenberg, J L Slangen

Abstract

Rats (N = 12) were trained to discriminate midazolam (1 mg/kg, IP) from vehicle in a food reinforced operant conditioning procedure. Midazolam, flunitrazepam, diazepam, chlordiazepoxide and pentobarbital showed dose-dependent substitution for midazolam. Buspirone and Ro 15-1788 did not substitute for midazolam. The midazolam cue was dose-dependently antagonized by Ro 15-1788. In rats (N = 12) trained to discriminate chlordiazepoxide (3 mg/kg, IP) from vehicle midazolam, flunitrazepam, diazepam and chlordiazepoxide substituted completely and dose dependently for chlordiazepoxide. The relative potency of chlordiazepoxide and diazepam was three times less in the midazolam-trained animals than in the chlordiazepoxide-trained animals. Response rate and latency data further support the main finding that the midazolam cue is similar, but not identical to the cue of classical benzodiazepines.

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Citations

Aug 21, 2013·Psychopharmacology·Lisa R Gerak, Charles P France
May 24, 1995·European Journal of Pharmacology·J B AcriJ M Witkin
May 1, 1990·Pharmacology, Biochemistry, and Behavior·C E LauM Tang
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·F Woudenberg, T H Hijzen
May 1, 1991·Pharmacology, Biochemistry, and Behavior·H J RijndersJ L Slangen
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·J G WettsteinW H Morse
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·N A Ator
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·M D Schechter
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·J B KamienJ R Hughes
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·N A Ator
Jun 1, 1997·Journal of Clinical Psychopharmacology·J H Woods, G Winger
May 1, 1995·Journal of the Experimental Analysis of Behavior·C R RushR R Griffiths
Jan 14, 2004·The Journal of Pharmacology and Experimental Therapeutics·Wouter KoekCharles P France

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