Discriminative stimulus properties of substituted amphetamine derivatives

Pharmacology, Biochemistry, and Behavior
W A CorrigallB A Lodge

Abstract

Animals were trained to discriminate amphetamine (1 mg/kg) from saline in a fixed-ratio (FR 10), food-reinforced paradigm. Amphetamine-appropriate responding was engendered by the training dose, and by 3 mg/kg, while at lower doses there was a progressive decrease in the extent of responding on the drug-appropriate lever. The following three novel amphetamine derivatives were tested for their ability to produce amphetamine-appropriate responding: 2,5-dimethoxy-4-ethoxy-amphetamine (DMEA); 2,5-dimethoxy-4-methylthio-amphetamine (DMMTA), and 2,4,5-trimethoxy-amphetamine (TMA). DMEA produced only minimal (< 20%) amphetamine-appropriate responding over a dose range of 0.1-10 mg/kg. Substantial decreases in response rate limited testing of the other amphetamines to a dose maximum of 3 mg/kg, but over the range of 0.1-3.0 mg/kg there was little evidence for generalization. At 3 mg/kg of either DMMTA or TMA, only 2 of 10 animals completed at least one uninterrupted FR 10 on either lever, and with either compound only 1 of these 2 animals responded more than 50% on the drug-appropriate lever. Of the three compounds tested, DMMTA had the greatest response rate-decreasing effect.

References

Mar 1, 1978·Drug and Alcohol Dependence·W R MartinL D Bright
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·W A CorrigallB A Lodge
May 1, 1985·Pharmacology, Biochemistry, and Behavior·R A GlennonA E Hauck
Sep 1, 1974·Pharmacology, Biochemistry, and Behavior·J T Huang, B T Ho

Citations

Aug 8, 1996·European Journal of Pharmacology·J H MaesJ M Vossen
Sep 23, 1997·Pharmacology, Biochemistry, and Behavior·J H Maes, J M Vossen
Mar 14, 1997·Drug and Alcohol Dependence·W L Woolverton, J A English
Nov 11, 1999·Medizinische Klinik·G F Combs

Related Concepts

Amphetamines
Metazoa
Discrimination (Process of Differentiation)
Discrimination Learning
Dose-Response Relationship, Drug
Reinforcement Schedule
Rats, Laboratory

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