Discriminative stimulus properties of the mixed agonist-antagonist pentazocine in the rat using two-choice discrete-trial avoidance paradigm

Pharmacology, Biochemistry, and Behavior
M UkaiT Kameyama

Abstract

The discriminative stimulus effects of pentazocine were evaluated in the rat trained to discriminate 3.0 mg/kg of pentazocine from vehicle in a two-choice discrete-trial avoidance paradigm. The rats used could discriminate 3.0 mg/kg of pentazocine from vehicle within 20 sessions after the start of discrimination training. The stimulus effects lasted 30 to 90 min and disappeared thereafter except for one rat in which the discriminative effects lasted 30 to 150 min. Pentazocine produced dose-dependent stimulus effects at 0.3 to 3.0 mg/kg doses. The stimulus effects of pentazocine were fully reversed by higher doses of naltrexone. Butorphanol, nalorphine, morphine, levorphanol, SKF 10,047, and methamphetamine generalized to pentazocine cue. However, ethylketocyclazocine, dextrorphan or pentobarbital did not produce stimulus effects in common with pentazocine. These results suggest that the discriminative stimulus effects of pentazocine (3.0 mg/kg) are mediated through an opioid but non-mu and nonspecific mechanism.

References

Jun 9, 1977·Nature·J A LordH W Kosterlitz
Nov 15, 1977·Psychopharmacology·I D Hirschhorn
Nov 10, 1976·Psychopharmacology·H E Shannon, S G Holtzman
Feb 1, 1985·Drug and Alcohol Dependence·S G Holtzman
Jan 1, 1988·Pharmacology, Biochemistry, and Behavior·M Ukai, S G Holtzman
Jun 1, 1974·European Journal of Pharmacology·G PaalzowB Stalby
Oct 1, 1972·European Journal of Pharmacology·A E TakemoriS E Smits

Related Concepts

Metazoa
Discrimination (Process of Differentiation)
Dose-Response Relationship, Drug
Madrine
Trexan
Narcotic Effect
Talwin
Diabutal
August Rats
Rats, Laboratory

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