Discriminative stimulus properties of physostigmine in rats

European Journal of Pharmacology
A H Tang, S R Franklin

Abstract

Sprague-Dawley rats were trained to discriminate a subcutaneous injection of physostigmine (0.2 mg/kg) from a similar injection of saline in a two-lever, food-reinforced behavior paradigm. The training dose of physostigmine reduced the response rate to about 50% of that in saline sessions. The discriminative stimulus (DS) effect of physostigmine is mediated by a central cholinergic mechanism since it was antagonized by scopolamine (0.1 mg/kg), but was unaffected by methylscopolamine (1 mg/kg) or pirenzepine (3 mg/kg). Neostigmine produced predominantly saline-appropriate lever choice. Compounds which produced averages of greater than 80% responses on the physostigmine lever are: compound BM-5 (N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)-acetamide), tetrahydroaminoacridine (THA), RS-86 (2-ethyl-8-methyl-2,8-diazaspiro-(4,5)-decan-1,3-dion hydrobromide), cis-AF30 (2-methyl-spiro-(1,3-dioxolane-4,3')-quinuclidine), and pilocarpine. In comparison, oxotremorine, aceclidine (3-acetoxy-quinuclidine), arecoline, and nicotine produced a maximum average responding of 40-70% on the physostigmine lever. The DS effect of physostigmine in rats appeared to involve a greater participation of M1 and M2 muscarinic or the nicotinic receptor in ...Continue Reading

References

Dec 21, 1976·Psychopharmacology·K L DavisK Train
Jan 1, 1987·Psychopharmacology·M JungP H Kelly
Dec 1, 1954·British Journal of Pharmacology and Chemotherapy·U TRENDELENBURG

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Citations

May 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·M D Schechter
Aug 1, 1997·Pharmacology, Biochemistry, and Behavior·B M Kelley, J H Porter
Jun 17, 1999·Pharmacology, Biochemistry, and Behavior·M M Makhay, J M O'Donnell
Oct 1, 1995·European Journal of Epidemiology·S Muntoni

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