Discriminative stimulus properties of pentobarbital and progesterone in male and female rats

Pharmacology, Biochemistry, and Behavior
R.P.W. HeinsbroekN.E. van De Poll


Intact male and ovariectomized female rats were trained to discriminate 12 mg/kg pentobarbital from physiological saline. Generalization tests with different doses of pentobarbital did not reveal significant sex differences in the pentobarbital generalization gradient. Different doses of progesterone produced a generalization gradient to pentobarbital in ovariectomized females, but not in intact males. The results of the present experiment thus suggests that systemic administration of progesterone produces a "pentobarbital-like" stimulus in ovariectomized female rats, but not in intact males.


Dec 1, 1985·Japanese Journal of Pharmacology·T SuzukiS Yanaura
May 1, 1967·International Journal of Neuropharmacology·L GyermekN Fleming
Dec 23, 1967·Nature·J StewartE Kaczender
Jan 1, 1971·European Journal of Pharmacology·R KatoY Omori
Jul 1, 1981·Journal of Neurochemistry·R W Olsen
May 1, 1982·Pharmacology, Biochemistry, and Behavior·I S Westenberg, J M Bolam


Jan 1, 1988·Physiology & Behavior·R.P.W. HeinsbroekN.E. van De Poll
Nov 1, 1995·Physiology & Behavior·B B GorzalkaL A Hanson
Jan 1, 1992·Psychoneuroendocrinology·R. de BeunN.E. van De Poll
Feb 1, 1992·Brain Research Bulletin·B W PeetersC L Broekkamp
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R. de Beun
Mar 1, 1989·Behavioural Brain Research·F van Haaren, A van Hest
Jul 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nancy K MelloJack H Mendelson
Oct 1, 2009·Future Medicinal Chemistry·C A Frye
Sep 19, 2006·Pharmacology, Biochemistry, and Behavior·C A Frye
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·F van HaarenR.P.W. Heinsbroek
Apr 29, 2005·The Journal of Pharmacology and Experimental Therapeutics·Erin E ShannonK A Grant
Oct 3, 2009·The Journal of Pharmacology and Experimental Therapeutics·Michelle G BaladiCharles P France

Related Concepts

Discrimination Learning
Bilateral Oophorectomy
Progesterone, (17 alpha)-Isomer
August Rats
Psychological Reinforcement
Rats, Laboratory

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.