Discriminative stimulus properties of pentobarbital and progesterone in male and female rats

Pharmacology, Biochemistry, and Behavior
R.P.W. HeinsbroekN.E. van De Poll

Abstract

Intact male and ovariectomized female rats were trained to discriminate 12 mg/kg pentobarbital from physiological saline. Generalization tests with different doses of pentobarbital did not reveal significant sex differences in the pentobarbital generalization gradient. Different doses of progesterone produced a generalization gradient to pentobarbital in ovariectomized females, but not in intact males. The results of the present experiment thus suggests that systemic administration of progesterone produces a "pentobarbital-like" stimulus in ovariectomized female rats, but not in intact males.

References

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Citations

Jan 1, 1988·Physiology & Behavior·R.P.W. HeinsbroekN.E. van De Poll
Nov 1, 1995·Physiology & Behavior·B B GorzalkaL A Hanson
Jan 1, 1992·Psychoneuroendocrinology·R. de BeunN.E. van De Poll
Feb 1, 1992·Brain Research Bulletin·B W PeetersC L Broekkamp
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R. de Beun
Mar 1, 1989·Behavioural Brain Research·F van Haaren, A van Hest
Jul 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nancy K MelloJack H Mendelson
Oct 1, 2009·Future Medicinal Chemistry·C A Frye
Sep 19, 2006·Pharmacology, Biochemistry, and Behavior·C A Frye
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·F van HaarenR.P.W. Heinsbroek
Apr 29, 2005·The Journal of Pharmacology and Experimental Therapeutics·Erin E ShannonK A Grant
Oct 3, 2009·The Journal of Pharmacology and Experimental Therapeutics·Michelle G BaladiCharles P France

Related Concepts

Metazoa
Discrimination Learning
Bilateral Oophorectomy
Diabutal
Progesterone, (17 alpha)-Isomer
August Rats
Psychological Reinforcement
Rats, Laboratory

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