PMID: 6291084Jan 1, 1982

Discriminative stimulus properties of naloxone

Psychopharmacology
R B Carter, J D Leander

Abstract

Nonopioid-dependent pigeons were trained to discriminate IM injections of 30.0 mg/kg naloxone from water in the procedure in which 15 consecutive responses on one of two keys resulted in grain presentation. Naloxone-appropriate responding was maximal at doses of naloxone equal to and greater than the training dose. The onset of the naloxone discriminative cue was rapid (less than 5 min) and the duration of the cue was short (less than 60 min). Naltrexone (1.0-10.0 mg/kg). pentazocine (1.0-10.0 mg/kg), levallorphan (1.0-30.0 mg/kg), and nalorphine (3.0-30.0 mg/kg) produced dose-dependent increases in naloxone-appropriate responding, occasioning 100% naloxone-key selections. In contrast, cyclazocine, profadol, and diprenorphine, at doses up to those at which animals did not respond, produced only intermediate degrees of naloxone-appropriate responding. Morphine always produced selection of the water key. These results demonstrate that a pure opioid antagonist, such as naloxone, has discriminative stimulus effects in the nonopioid-dependent animals, that these stimulus effects are shared by certain other opioid antagonists, and that these effects are distinguishable from those produced by pure opioid agonists, such as morphine.

References

Jan 1, 1977·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·E Doshi, S E Huggins
Dec 1, 1978·Pharmacology, Biochemistry, and Behavior·F C Colpaert
Nov 15, 1977·Psychopharmacology·I D Hirschhorn
Jan 1, 1978·European Journal of Pharmacology·R DingledineE Breuker
Mar 16, 1976·Psychopharmacologia·F C ColpaertP A Janssen

Citations

Jan 22, 1985·European Journal of Pharmacology·K A CunninghamJ B Appel
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·M D Schechter
Mar 1, 1988·Pharmacology, Biochemistry, and Behavior·R A GlennonG Patrick
Feb 1, 1988·Pharmacology, Biochemistry, and Behavior·A H OlivetoL A Dykstra
Dec 1, 1988·Pharmacology, Biochemistry, and Behavior·M D Schechter
May 1, 1988·Pharmacology, Biochemistry, and Behavior·S A Signs, M D Schechter
Apr 1, 1990·Pharmacology, Biochemistry, and Behavior·S M EvansC E Johanson
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·S T SmurthwaiteA L Riley
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·R A Glennon, R Higgs
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, A L Riley
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·S Pournaghash, A L Riley
Nov 1, 1994·Pharmacology, Biochemistry, and Behavior·M V GewissC W Schindler
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·D White-Gbadebo, S G Holtzman
Jan 1, 1996·Behavioural Brain Research·S M Meehan, M D Schechter
Jul 1, 1983·Peptides·G A OlsonA J Kastin
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·M DukatR A Glennon
May 1, 1997·Pharmacology, Biochemistry, and Behavior·R A GlennonY Cheng
Aug 1, 1997·Pharmacology, Biochemistry, and Behavior·L E Baker, M M Taylor
May 1, 1997·Pharmacology, Biochemistry, and Behavior·R Young, R A Glennon
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Berend OlivierJef L Slangen
Mar 24, 2006·Psychosomatic Medicine·Michael UssherFrank Hucklebridge
Dec 31, 1997·The Veterinary Quarterly·M D Zaal, H A Hazewinkel

Related Concepts

Discrimination Learning
Dose-Response Relationship, Drug
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Narcotic Antagonists
Columba livia
Hormone Receptors, Cell Surface
GABA-A Receptor gamma Subunit

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