PMID: 829208Jan 1, 1976

Discussion paper: the use of glutaraldehyde fixation for the study of the immune response to syngeneic tumor antigen

Annals of the New York Academy of Sciences
P FrostC J Sanderson

Abstract

We have been able to demonstrate that glutaraldehyde fixation of tumor cells or tumor cell membrane fragments protect syngeneic mice against the subsequent challenge with viable cells. To date we have not been able to detect any antibody against the tumor cells in animals so immunized. The specificity of the response is not complete, although a major component of the protective effect of glutaraldehyde-treated tumor cells is immunologically specific.

Related Concepts

Aldehydes
Tumor Antibodies
Fixatives
Sekumatic
Cellular Immune Response
Variolation
Tissue Membrane
Mice, Inbred BALB C
Sarcoma, Jensen

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