Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.

Acta Neuropathologica Communications
Ethan HassBenoit I Giasson


Synucleinopathies, including Parkinson's disease (PD), Lewy body dementia (LBD), Alzheimer's disease with amygdala restricted Lewy bodies (AD/ALB), and multiple system atrophy (MSA) comprise a spectrum of neurodegenerative disorders characterized by the presence of distinct pathological α-synuclein (αSyn) inclusions. Experimental and pathological studies support the notion that αSyn aggregates contribute to cellular demise and dysfunction with disease progression associated with a prion-like spread of αSyn aggregates via conformational templating. The initiating event(s) and factors that contribute to diverse forms of synucleinopathies remain poorly understood. A major post-translational modification of αSyn associated with pathological inclusions is a diverse array of specific truncations within the carboxy terminal region. While these modifications have been shown experimentally to induce and promote αSyn aggregation, little is known about their disease-, region- and cell type specific distribution. To this end, we generated a series of monoclonal antibodies specific to neo-epitopes in αSyn truncated after residues 103, 115, 119, 122, 125, and 129. Immunocytochemical investigations using these new tools revealed striking diff...Continue Reading


May 23, 1994·FEBS Letters·R JakesM Goedert
Jul 4, 2001·Nature Reviews. Neuroscience·M Goedert
Nov 1, 2003·Science·A B SingletonK Gwinn-Hardy
Feb 3, 2004·Annals of Neurology·Juan J ZarranzJusto G de Yebenes
Feb 3, 2004·Annals of Neurology·Matt FarrerJ William Langston
Sep 29, 2004·Lancet·Marie-Christine Chartier-HarlinAlain Destée
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Wenxue LiMichael K Lee
Jun 15, 2005·Annual Review of Biochemistry·Mark R Cookson
Nov 15, 2005·Journal of Neural Transmission·D W MillerA B Young
Jul 11, 2006·Journal of Neuropathology and Experimental Neurology·Hirotake UchikadoDennis W Dickson
Nov 2, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Heiko BraakKelly Del Tredici
Apr 26, 2007·The American Journal of Pathology·Brian M DuftyTroy T Rohn
Oct 29, 2008·Biochimica Et Biophysica Acta·Elisa A Waxman, Benoit I Giasson
Jan 24, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bradley T HymanThomas J Montine
Nov 28, 2012·Nature Reviews. Neurology·Michel GoedertHeiko Braak
Feb 22, 2013·Neurology·Christos ProukakisAnthony H Schapira
Mar 5, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Silke Appel-CresswellMatthew J Farrer
Mar 26, 2013·Annals of Neurology·Suzanne LesageUNKNOWN French Parkinson's Disease Genetics Study Group
Jul 11, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dora GamesEliezer Masliah
Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ryan P McGlinchey, Jennifer C Lee
Oct 16, 2015·Biochimica Et Biophysica Acta·Laura PieriVirginie Redeker
Dec 1, 2015·Journal of Neurochemistry·Trevor TysonPatrik Brundin
Jul 19, 2016·Journal of Neurochemistry·Amanda N SacinoBenoit I Giasson
Sep 14, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Yvette C Wong, Dimitri Krainc
Jul 4, 2017·Nature Structural & Molecular Biology·Zhentao ZhangKeqiang Ye

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