Disease activity and disability in children with juvenile idiopathic arthritis one year following presentation to paediatric rheumatology. Results from the Childhood Arthritis Prospective Study.

Rheumatology
K HyrichWendy Thomson

Abstract

Inflammatory arthritis in childhood is variable in terms of both presentation and outcome. This analysis describes disease activity in children with juvenile idiopathic arthritis (JIA) during the first year following presentation to a paediatric rheumatologist and identifies predictors of moderate to severe disability [defined using a Childhood HAQ (CHAQ) score >or=0.75] at 1 year. The Childhood Arthritis Prospective Study recruits children <16 years with new inflammatory arthritis persisting for >or=2 weeks from five UK tertiary referral centres. Demographics, disease features, joint count, CHAQ, physician's global assessment, parent's general evaluation of well-being (PGE), ESR and treatment, are collected at first presentation, 6 months and then yearly. Independent predictors of CHAQ >or=0.75 at 1 year in children diagnosed with JIA were identified using multivariable logistic regression models. Seven hundred and forty children with JIA were included; median age at presentation 7.6 years, 64% girls. During the first year, 85% received NSAIDs, 70% IA corticosteroids, 47% MTX and 27% systemic steroids (oral or i.v.). Median presenting CHAQ score was 0.63 and decreased to 0.25 at 1 year; 32% had CHAQ >or=0.75 at 1 year. The str...Continue Reading

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Citations

May 1, 2010·Rheumatology·Despina EleftheriouPaul A Brogan
Dec 22, 2012·Annals of the Rheumatic Diseases·Flora McErlaneUNKNOWN Childhood Arthritis Prospective Study (CAPS)
Oct 12, 2012·Pediatric Rheumatology Online Journal·Kate WeakleyChristiaan Scott
Aug 4, 2012·The Journal of Rheumatology·Timothy BeukelmanUNKNOWN CARRA Registry Investigators
Jun 3, 2014·Arthritis Research & Therapy·Adam StevensRachelle P Donn
Jun 26, 2014·Annals of the Rheumatic Diseases·E H Pieter van Dijkhuizen, Nico M Wulffraat
Mar 12, 2016·International Journal of Inflammation·Mohammad H Al-HemairiMohammed A Muzaffer
May 21, 2014·Annals of the Rheumatic Diseases·Jaime GuzmanUNKNOWN ReACCh-Out investigators
Sep 16, 2015·Archives of Disease in Childhood·Kimme L HyrichWendy Thomson
Oct 28, 2015·Journal of Immunology Research·Ana Filipa MourãoHelena Canhão
Jul 6, 2014·Rheumatology·Elizabeth J CoulsonHelen E Foster
Jun 17, 2016·International Journal of Rheumatic Diseases·Nisha Vengassery Balakrishnan MenonRiazudeen Arakkal
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Neil MartinLucy R Wedderburn
Nov 28, 2017·Archives of Disease in Childhood·Amir RashidWendy Thomson
Mar 12, 2017·Rheumatology International·Mikel Alberdi-SaugstrupUNKNOWN Nordic Study Group of Pediatric Rheumatology (NoSPeR)
Jun 26, 2020·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Claudia SenglerKirsten Minden
May 1, 2021·Pediatric Rheumatology Online Journal·Yung-Hsien HuangYao-Hsu Yang
Aug 28, 2021·Children·Emil CarlssonChristian M Hedrich
Jan 29, 2022·Nature Reviews. Disease Primers·Alberto MartiniNicolino Ruperto

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