Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease

Nature Communications
Kate L BowermanPhilip M Hansbro

Abstract

Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death globally, and manifests as a progressive inflammatory lung disease with no curative treatment. The lung microbiome contributes to COPD progression, but the function of the gut microbiome remains unclear. Here we examine the faecal microbiome and metabolome of COPD patients and healthy controls, finding 146 bacterial species differing between the two groups. Several species, including Streptococcus sp000187445, Streptococcus vestibularis and multiple members of the family Lachnospiraceae, also correlate with reduced lung function. Untargeted metabolomics identifies a COPD signature comprising 46% lipid, 20% xenobiotic and 20% amino acid related metabolites. Furthermore, we describe a disease-associated network connecting Streptococcus parasanguinis_B with COPD-associated metabolites, including N-acetylglutamate and its analogue N-carbamoylglutamate. While correlative, our results suggest that the faecal microbiome and metabolome of COPD patients are distinct from those of healthy individuals, and may thus aid in the search for biomarkers for COPD.

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Citations

Apr 20, 2021·Frontiers in Nutrition·Emma E Hamilton-WilliamsJessica L Dunne
Jun 1, 2021·Frontiers in Microbiology·Tao FengÁkos Kenéz
Jun 3, 2021·Nutrients·Christophe Espírito SantoInês Brandão
May 31, 2021·Trends in Microbiology·Andrea IorioLorenza Putignani
Jun 18, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Sarah K KirschnerMariëlle P K J Engelen
Oct 16, 2021·Thorax·Rachel S KellyJessica A Lasky-Su
Nov 21, 2021·Nature Communications·Yongzhi YangYanlei Ma

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Methods Mentioned

BETA
bronchoalveolar lavage
amplicon sequencing
metabolomic profiling
PCR
PCA

Software Mentioned

Mosdepth
DADA2
BamM
heatmap
Oracle
R
DIABLO
Microba
MixOmics
Metabat

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