Disease-Associated Plasmacytoid Dendritic Cells

Frontiers in Immunology
Shuang LiJingtao Chen

Abstract

Plasmacytoid dendritic cells (pDCs), also called natural interferon (IFN)-producing cells, represent a specialized cell type within the innate immune system. pDCs are specialized in sensing viral RNA and DNA by toll-like receptor-7 and -9 and have the ability to rapidly produce massive amounts of type 1 IFNs upon viral encounter. After producing type 1 IFNs, pDCs differentiate into professional antigen-presenting cells, which are capable of stimulating T cells of the adaptive immune system. Chronic activation of human pDCs by self-DNA or mitochondrial DNA contributes to the pathogenesis of systemic lupus erythematosis and IFN-related autoimmune diseases. Under steady-state conditions, pDCs play an important role in immune tolerance. In many types of human cancers, recruitment of pDCs to the tumor microenvironment contributes to the induction of immune tolerance. Here, we provide a systemic review of recent progress in studies on the role of pDCs in human diseases, including cancers and autoimmune/inflammatory diseases.

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Citations

Feb 15, 2020·Cells·Matilde MontiWilliam Vermi
May 17, 2019·Journal of Immunology Research·Jing WuJingtao Chen
Dec 11, 2019·The Journal of Experimental Medicine·Hung-Jen ChenMenno P J de Winther
Jan 9, 2019·Frontiers in Immunology·Chunmei Fu, Aimin Jiang
Sep 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Chunmei FuAimin Jiang
Dec 2, 2020·Vaccines·Chunmei FuAimin Jiang
Jun 7, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shan ZhuJingtao Chen
Oct 5, 2020·Seminars in Immunology·Johanna VerneauCheng-Ming Sun
May 1, 2021·International Journal of Molecular Sciences·Dóra BenczeKitti Pázmándi
May 7, 2021·Oncotarget·Kavin FatehchandJonathan P Butchar
Aug 8, 2021·Cancers·Yi YaoAimin Jiang

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Methods Mentioned

BETA
nuclear translocation

Clinical Trials Mentioned

NCT02692976
NCT02574377
NCT01690377
NCT00960752

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