Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis

PLoS Medicine
Jeffrey T HuangSabine Bahn


Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional beliefs. There are numerous psychiatric conditions that present with psychotic symptoms, most importantly schizophrenia, bipolar affective disorder, and some forms of severe depression referred to as psychotic depression. The pathological mechanisms resulting in psychotic symptoms are not understood, nor is it understood whether the various psychotic illnesses are the result of similar biochemical disturbances. The identification of biological markers (so-called biomarkers) of psychosis is a fundamental step towards a better understanding of the pathogenesis of psychosis and holds the potential for more objective testing methods. Surface-enhanced laser desorption ionization mass spectrometry was employed to profile proteins and peptides in a total of 179 cerebrospinal fluid samples (58 schizophrenia patients, 16 patients with depression, five patients with obsessive-compulsive disorder, ten patients with Alzheimer disease, and 90 controls). Our results show a highly significant differential distribution of samples from healthy volunteers away from drug-naïve patients with ...Continue Reading


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Methods Mentioned

enzyme-linked immunosorbent assay

Related Concepts

VGF protein, human
Neurite Outgrowth Factors
Peptide Fragments
Schizophreniform Disorders
Delusional Disorder
Viral Markers
Receptor Down-Regulation

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