Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis

PLoS Medicine
Jeffrey T HuangSabine Bahn

Abstract

Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional beliefs. There are numerous psychiatric conditions that present with psychotic symptoms, most importantly schizophrenia, bipolar affective disorder, and some forms of severe depression referred to as psychotic depression. The pathological mechanisms resulting in psychotic symptoms are not understood, nor is it understood whether the various psychotic illnesses are the result of similar biochemical disturbances. The identification of biological markers (so-called biomarkers) of psychosis is a fundamental step towards a better understanding of the pathogenesis of psychosis and holds the potential for more objective testing methods. Surface-enhanced laser desorption ionization mass spectrometry was employed to profile proteins and peptides in a total of 179 cerebrospinal fluid samples (58 schizophrenia patients, 16 patients with depression, five patients with obsessive-compulsive disorder, ten patients with Alzheimer disease, and 90 controls). Our results show a highly significant differential distribution of samples from healthy volunteers away from drug-naïve patients with ...Continue Reading

References

Apr 1, 1986·Biological Psychiatry·T P BeresfordR C Hall
Dec 1, 1969·Archives of General Psychiatry·H MeltzerR A Moline
Mar 1, 1982·Archives of Internal Medicine·J E Morley, R B Shafer
Feb 10, 1997·The Journal of Comparative Neurology·J P Wisor, J S Takahashi
Feb 14, 1998·European Journal of Endocrinology·C Kirkegaard, J Faber
Nov 26, 1999·European Psychiatry : the Journal of the Association of European Psychiatrists·H VolzH Sauer
Jul 7, 2000·Frontiers in Neuroendocrinology·S R J SaltonAndrea Levi
Jun 1, 2001·Nature Medicine·G K Thaker, W T Carpenter
Aug 11, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Reiber
Feb 28, 2002·Nature Neuroscience·Andreas Meyer-LindenbergKaren Faith Berman
Nov 20, 2003·Mass Spectrometry Reviews·Ning TangScot R Weinberger
Apr 23, 2004·Current Opinion in Biotechnology·Emanuel F Petricoin, Lance A Liotta
May 19, 2004·The European Journal of Neuroscience·J E SwattonSabine Bahn
Jul 6, 2004·Cellular and Molecular Neurobiology·Andrea LeviS R J Salton
Dec 8, 2004·The European Journal of Neuroscience·Salvatora SuccuAntonio Argiolas
Jul 22, 2005·PLoS Medicine·Patrick F Sullivan
Sep 13, 2005·Experimental Neurology·Ulla RüetschiKaj Blennow
Nov 30, 2005·Journal of Neurochemistry·Srikanth RanganathanRobert Bowser
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Smita Thakker-VariaJanet Alder

Citations

Feb 3, 2012·Biomarkers in Medicine·Hong I WanJeffrey F Waring
May 24, 2014·European Psychiatry : the Journal of the Association of European Psychiatrists·Y ZhanP Xie
Feb 1, 2012·Acta Neuropsychiatrica·Li ShaB S Pickard
Aug 23, 2007·PloS One·Jeffrey T HuangSabine Bahn
Oct 14, 2008·Genes & Nutrition·Alessandro BartolomucciAnna Moles
Mar 19, 2009·Proteome Science·Jayme WiederinPawel Ciborowski
Jun 2, 2009·Human Molecular Genetics·Viviane LabrieJohn C Roder
Dec 10, 2009·European Archives of Psychiatry and Clinical Neuroscience·Daniel Martins-de-SouzaSabine Bahn
Feb 13, 2010·International Archives of Medicine·Shaheen E LakhanElissa Hamlat
Aug 25, 2011·Endocrine Reviews·Alessandro BartolomucciS R J Salton
Jul 29, 2011·Expert Reviews in Molecular Medicine·B S Pickard
Apr 18, 2008·The Cerebellum·S Hossein FatemiRobert W Sidwell
Feb 26, 2016·Frontiers in Cellular Neuroscience·Katarina DavalievaAndrew J Dwork
Jul 7, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·K Bechter
Jun 15, 2011·Progress in Neurobiology·Viola Oertel-KnöchelHarald Hampel
Apr 2, 2014·Journal of Proteome Research·Fei LiFrank J Gonzalez
Aug 12, 2009·Progress in Neurobiology·Carolina Estima FlemingMónica Mendes Sousa
Nov 1, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Daniëlle de JongMarcel M Verbeek
Nov 6, 2008·Behavioural Brain Research·Smita Thakker-Varia, Janet Alder
Nov 22, 2008·Toxicology Letters·Marcel Ferrer-AlcónAntonio Martinez
May 2, 2008·Biochemical and Biophysical Research Communications·Kagemasa KajiwaraMinoru Kimura
Jan 2, 2008·Journal of Affective Disorders·Kristofer SchultzAsa Petersén
Oct 1, 2008·Proteomics. Clinical Applications·Wojciech RozekPawel Ciborowski
Jan 15, 2008·British Journal of Pharmacology·Emanuel Schwarz, Sabine Bahn
Apr 24, 2012·Annals of Neurology·Mika KomoriTakayuki Kondo
Jul 8, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chad A BousmanIan P Everall
Mar 24, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Donald C GoffSteven G Potkin
Nov 21, 2013·Biomedical Chromatography : BMC·Na ZhouQiong Yu
Oct 23, 2012·Psychoneuroendocrinology·Laura W HarrisSabine Bahn
Aug 22, 2013·Journal of Psychiatric Research·Giuseppina MaccarroneChristoph W Turck
Aug 11, 2012·PloS One·Mikko HölttäJohan Gobom
Aug 30, 2016·Expert Review of Proteomics·Laura GiustiAntonio Lucacchini
Feb 10, 2010·Journal of Psychopharmacology·Regina TaurinesJohannes Thome
Apr 11, 2017·Critical Reviews in Clinical Laboratory Sciences·Paulo BastosRui Vitorino
Dec 20, 2012·Molecular & Cellular Proteomics : MCP·Kazuki SasakiNaoto Minamino
Mar 20, 2008·Molecular & Cellular Proteomics : MCP·Rachel M CraddockSabine Bahn
Mar 4, 2017·Forensic Science International. Genetics·Athina VidakiDenise Syndercombe Court
Oct 27, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Andrea SchmittMembers of the WFSBP Task Force on Biological Markers
Jul 27, 2012·Translational Psychiatry·N MomeniB L Persson
Mar 8, 2007·Nature Medicine·Olavo B Amaral
Nov 22, 2018·Neurochemical Research·Takahiro MizoguchiHideaki Hara
Jun 3, 2008·Electrophoresis·Emanuel Schwarz, Sabine Bahn
Oct 8, 2014·Acta Neuropsychiatrica·Marat UzbekovTatjana Moskvitina
Apr 28, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Gerald StoberPeter Riederer
Nov 26, 2009·Expert Review of Proteomics·Nicoletta Baloyianni, George Th Tsangaris
Feb 8, 2011·European Archives of Psychiatry and Clinical Neuroscience·Laura KranasterF Markus Leweke
May 1, 2019·Cellular and Molecular Neurobiology·Takahiro MizoguchiMasamitsu Shimazawa
Feb 2, 2012·Expert Review of Proteomics·Daniel Martins-de-SouzaSabine Bahn
Dec 17, 2011·European Archives of Psychiatry and Clinical Neuroscience·Nenad VasicJohannes Brettschneider
Sep 26, 2007·Expert Review of Molecular Diagnostics·Malcolm Ward
Sep 17, 2009·Biochemical Society Transactions·Robin S B Williams
Jun 20, 2017·Frontiers in Cellular Neuroscience·Barbara NoliCristina Cocco
Apr 14, 2018·Pharmacological Reports : PR·Takahiro MizoguchiHideaki Hara
Jul 5, 2007·The Journal of Biological Chemistry·Hideki YamaguchiNaoto Minamino
May 8, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Daniel Martins-de-SouzaChristoph W Turck
Jan 1, 2015·NPJ Schizophrenia·Juliana M Nascimento, Daniel Martins-de-Souza
Mar 28, 2008·Expert Review of Molecular Diagnostics·Emanuel Schwarz, Sabine Bahn
Jul 12, 2017·Case Reports in Psychiatry·Lilibet Urias-UribeAldo Ferreira-Hermosillo
Jun 1, 2019·Annual Review of Nutrition·Kendra A TianiMartha S Field
Jul 7, 2017·Scientific Reports·Takahiro MizoguchiHideaki Hara
Feb 18, 2009·The Medical Journal of Australia·Richard Banati, Ian B Hickie
Oct 22, 2008·Neurobiology of Disease·Min ShiJing Zhang

Methods Mentioned

BETA
chips
chip
enzyme-linked immunosorbent assay
ELISA
electrophoresis
PCA

Related Concepts

VGF protein, human
Brain
Neurite Outgrowth Factors
Peptide Fragments
Prealbumin
Schizophreniform Disorders
Schizophrenia
Delusional Disorder
Viral Markers
Receptor Down-Regulation

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