Disease burden of enterovirus infection in Taiwan: Implications for vaccination policy

Vaccine
Ding-Ping LiuMing-Chin Yang

Abstract

This study aimed to assess the disease burden and economic impacts of human nonpolio enteroviruses (NPEV) and enterovirus A71 (EV-A71) infection in Taiwan. We included children under five years old (n=983,127-1,118,649) with ICD-9-CM codes 0740 (herpangina) or 0743 (hand-foot-and-mouth disease) from the 2006 to 2010 National Health Insurance Database. Severity of enterovirus infection was assessed from outpatient/emergency visits, hospitalization (with/without intensive care unit [ICU] admission), infection with severe complications, and death. We estimated medical costs and indirect costs from the societal perspective. The annual rates of NPEV events for children under five years old ranged from 13.9% to 38.4%, of which 5.1-8.8% were hospitalized. EV-A71 accounted for 7.8% of all NPEV medical costs, but 79.1% of NPEV ICU costs. Travel costs and productivity loss of caregivers were $37.1 (range: $24.5-$64.7) million per year. These costs were not higher in the EV-A71 dominant year ($34.4 million) compared with those in the other years. Productivity losses resulting from premature mortality by NPEV infection were $0.8 (range: $0.0-$2.9) million per year, of which 96.3% were caused by EV-A71. Diseases associated with NPEV other t...Continue Reading

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Citations

Oct 17, 2017·European Journal of Clinical Investigation·Jun-Jun YehWu-Huei Hsu
May 31, 2018·The Pediatric Infectious Disease Journal·Yuka MurofushiIsao Miyairi
Apr 30, 2019·The Pediatric Infectious Disease Journal·TienYu Owen YangWan-Ting Huang
Mar 4, 2020·PLoS Neglected Tropical Diseases·Fang-Lin KuoMin-Shi Lee
Aug 1, 2019·Open Forum Infectious Diseases·Le Nguyen Thanh NhanLe Van Tan
Aug 10, 2019·Journal of Biomedical Science·Luan-Yin ChangTzou-Yien Lin
Oct 22, 2020·BMC Infectious Diseases·Chen-Wei HuangYhu-Chering Huang

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