Disease classification and transmission effects on linkage analyses in the NIMH1 bipolar disorder pedigrees

Genetic Epidemiology
J S Collins, R C Go

Abstract

In this analysis of bipolar affective disorder, 22 families from the NIMH1 data set were further grouped into three transmission patterns: male to male, male to female, and maternal. The data were analyzed under three classifications of affection status: Bipolar I (BPI) only, BPI and Bipolar II (BPII), and BPI, BPII, and recurrent unipolar. LINKAGE was run on each of the subsets, and SIBPAL was run on the full and grouped data sets. A lod score of 1.09 was found for marker D18S62 in the maternal subset, when classifying affecteds as BPI, BPII, or recurrent unipolar. Affected sib-pair analysis showed evidence for linkage with markers D18S62, D18S37, D18S53, D18S40, D18S45, and D18S56 in the male to male transmission groups and the full data set. Linkage was not consistently found in the maternal and father/daughter groups. These results indicate that subsetting by parental transmission may result in less heterogeneity and have significant effects on linkage findings. Studies using a broader definition of affection status may provide considerably more information for linkage.

References

Apr 1, 1978·The American Journal of Psychiatry·R J Cadoret
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M LathropJ Ott
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·W H BerrettiniE S Gershon
Oct 9, 1995·American Journal of Medical Genetics·M A SpenceR A Remick
Nov 1, 1995·Acta Psychiatrica Scandinavica·M Grigoroiu-SerbanescuV Ardelean
Apr 1, 1996·Nature Genetics·N Risch, D Botstein
Dec 5, 1996·Nature·C O'Brien

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Citations

Jan 31, 2014·American Journal of Medical Genetics. Part a·Ayse Gul ZamaniEbru Tuncez
Aug 31, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·O MukherjeeS Jain

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