DISEASE EXPRESSION IN NONEXUDATIVE AGE-RELATED MACULAR DEGENERATION VARIES WITH CHOROIDAL THICKNESS

Retina
Richard F Spaide

Abstract

To investigate the relationship between subfoveal choroidal thickness and disease manifestation in a series of eyes with nonexudative age-related macular degeneration (AMD). Retrospective study of eyes with nonexudative AMD. The extracellular deposits present, drusen and subretinal drusenoid deposits (SDD, pseudodrusen) along with a newly recognized form of drusen, pachydrusen, were graded and compared with choroidal thickness as determined by optical coherence tomography. Demographic and imaging information was evaluated with descriptive statistics and generalized estimating equations. There were 94 eyes of 71 patients, who had a mean age of 78.1 years. Soft drusen alone were found in 45 eyes (47.9%) and subretinal drusenoid deposit with or without drusen in 38 (40.4%). Pachydrusen, which were typically larger than 125 μm, often had an irregular outer contour, showed a scattered distribution over the posterior pole and occurred in isolation or in groups of only a few drusen were found in 11 (11.7%). The mean subfoveal choroidal thickness in the soft drusen group was 227.9 μm, in the subretinal drusenoid deposit group 167.3 μm, and in the pachydrusen group 419 μm. The differences between the groups were highly significant. Extr...Continue Reading

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Jul 12, 2018·Eye·Chui Ming Gemmy CheungK Bailey Freund
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Sean T GarritySrinivas R Sadda
Apr 3, 2019·Investigative Ophthalmology & Visual Science·Eleonora CorbelliGiuseppe Querques
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Oct 3, 2020·Scientific Reports·Miho TagawaAkitaka Tsujikawa
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Mar 16, 2021·Progress in Retinal and Eye Research·Elon H C van Dijk, Camiel J F Boon
Apr 7, 2021·Scientific Reports·Kelvin Yi Chong TeoChui Ming Gemmy Cheung

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