PMID: 7023651Sep 15, 1981Paper

Disease-free survival at intervals during and following completion of adjuvant chemotherapy: the NSABP experience from three breast cancer protocols

Cancer
B FisherH S Wieand

Abstract

Findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) trials evaluating three different regimens of adjuvant chemotherapy (L-PAM, L-PAM + 5-FU, L-PAM + 5-FU + MTX) in patients with primary breast cancer and positive axillary nodes indicate that each regimen has significantly contributed toward achieving the initial goal of such therapy, namely to diminish or prevent treatment failure in all or major subsets of patients during the first two years following operation when women are at greatest risk for a recurrence. Because of this hazard, chemotherapy was administered in all protocols for two years. Findings were examined at the end of the first year of therapy and at the termination of the second year for those who entered that year of therapy disease-free in order to determine whether the second year of treatment contributed a benefit beyond that achieved from the first year of therapy. A reduction in the incidence of treatment failure was evident in every subgroup of patients at completion of the first year of therapy. There was evidence of added improvement during the second year of treatment in patients aged 49 years or younger but not in those aged 50 years or older. Despite the finding, it is not p...Continue Reading

Citations

Oct 12, 2000·Journal of Surgical Oncology·B F Rush
Jan 1, 1985·Cancer Metastasis Reviews·Y T Lee
Jan 1, 1983·Breast Cancer Research and Treatment·J H Goldie
Jan 1, 1983·Breast Cancer Research and Treatment·H BrinckerK W Andersen
Jan 1, 1982·Breast Cancer Research and Treatment·D R OwnbyM J Brennan
Jan 1, 1986·Breast Cancer Research and Treatment·C J van de VeldeG G Giacco
Jan 1, 1986·Breast Cancer Research and Treatment·R T ChlebowskiJ R Bateman
Jan 1, 1984·Pharmacology & Therapeutics·B J Furr, V C Jordan
Jan 1, 1987·International Journal of Radiation Oncology, Biology, Physics·G DeloucheJ M Kurtz
Apr 1, 1986·International Journal of Radiation Oncology, Biology, Physics·V T DeVitaS A Rosenberg
Jan 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R D Rubens
Aug 1, 1985·Seminars in Oncology Nursing·C L Vogel
Dec 1, 1983·European Journal of Cancer & Clinical Oncology·H T Mouridsen, T Palshof
Aug 1, 1985·Journal of Surgical Oncology·K DabskiH L Stoll
Sep 1, 1986·Journal of the American Geriatrics Society·C AllenH J Cohen
Jun 11, 1999·Hematology/oncology Clinics of North America·P N Münster, C A Hudis
Nov 1, 2015·Journal of the National Cancer Institute·Ismail JatoiNorman Wolmark
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A WilsR C Coombes
Feb 15, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Philip M SpanheimerRonald J Weigel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
C A HubayW L McGuire
© 2021 Meta ULC. All rights reserved