PMID: 9420249Jan 7, 1998Paper

Disease induction by virus derived from molecular clones of equine infectious anemia virus

Journal of Virology
S L PayneF Fuller

Abstract

Equine infectious anemia virus (EIAV), a macrophage-tropic lentivirus, causes persistent infections of horses. A number of biologic features, including the rapid development of acute disease, the episodic nature of chronic disease, the propensity for viral genetic variation, and the ability for many infected animals to eventually control virus replication, render EIAV a potentially useful model system for the testing of antiretroviral therapies and vaccine strategies. The utility of the EIAV system has been hampered by the lack of proviral clones that encode promptly pathogenic viral stocks. In this report, we describe the generation and characterization of two infectious molecular clones capable of causing acute clinical syndromes similar to those seen in natural infections. Virus derived from clone p19/wenv17 caused severe debilitating disease at 5 to 7 days postinfection; initial febrile episodes were fatal in two of three infected animals. Virus derived from a second clone, p19/wenv16, caused somewhat milder primary febrile episodes by 10 to 12 days postinfection in two of two infected animals. Virus derived from both clones caused persistent infections such that some animals exhibited chronic equine infectious anemia, char...Continue Reading

References

Mar 1, 1987·Journal of Virology·D DerseJ W Casey
Jan 1, 1970·Archiv für die gesamte Virusforschung·Y KonoY Fukanaga
Feb 1, 1994·The Journal of General Virology·S L PayneF Fuller

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Citations

Jun 17, 1998·Journal of Biomedical Science·W Maury
Jan 29, 2003·Journal of Virology·Wendy MaurySarahann Bradley

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