PMID: 22583439May 16, 2012Paper

Disease modifying drugs in multiple sclerosis: mechanisms of action and new drugs in the horizon

CNS & Neurological Disorders Drug Targets
Monica Marta, Gavin Giovannoni

Abstract

The term "disease modifying drugs" (DMD) is taken from rheumatologists who coined it after the use of immunosuppressive drugs and, more recently, the association of "biological drugs" that changed the degenerative course of rheumatic disease. In the treatment of multiple sclerosis (MS), the advent of interferon (IFN)-β, which caused a reduction in the number of relapses and possibly improvement in disability outcomes, was the first strategy to prevent inflammatory damage in the central nervous system (CNS). Soon after, glatiramer acetate showed similar results. It would be more than a decade before natalizumab was licensed, showing a much better efficiency in relapse reduction than was seen after first-line therapies failed. The pipeline is now much larger with several drugs on the horizon. Overall, the anti-inflammatory strategy has been mostly successful but drugs that have protection and repair mechanisms are still missing.

Citations

Jul 19, 2013·Clinical Drug Investigation·Ching-Piao Tsai, Charles Tzu-Chi Lee
Jul 11, 2013·BMC Systems Biology·Inna PertsovskayaPablo Villoslada
Nov 30, 2013·Brain : a Journal of Neurology·Sarah Al-IzkiDavid Baker
Aug 13, 2015·Multiple Sclerosis and Related Disorders·David Baker, Sandra Amor
Oct 7, 2015·Journal of the Neurological Sciences·Mojtaba FarjamAbdolmohamad Rostami
Apr 12, 2016·Proteomics. Clinical Applications·Piero Del BoccioDamiana Pieragostino
Sep 5, 2015·Journal of Neuroinflammation·Yohannes HaileFabrizio Giuliani
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Apr 16, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Ching-Piao TsaiCharles Tzu-Chi Lee
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