Disease-Modifying Effects of Neural Regeneration Peptide 2945 in the GAERS Model of Absence Epilepsy

Neurochemical Research
Gabi DezsiNigel C Jones

Abstract

Epilepsy is a common neurological condition characterised by spontaneous recurrent seizures. Current anti-epileptic drugs are only effective and tolerated in ~70% of patients, leaving a substantial proportion of patients untreated. As such, there is a pressing need to develop new therapies. We assessed the anti-seizure activity of Neural Regeneration Peptide 2945 (NRP 2945) in the GAERS model of absence epilepsy. Drug effects on seizures were assessed using two study designs. Male adult GAERS were implanted with EEG electrodes to measure seizure frequency. The first study compared the effects of acute sc injection of vehicle, NRP 10 µg/kg, NRP 20 µg/kg, and controlled against the active comparator Valproaic acid (200 mg/kg). In the second study, animals received one of four treatments for 4 weeks: vehicle, NRP 60 µg/kg/day, NRP 120 µg/kg/day (delivered by continuous infusion) or NRP 20 µg/kg sc injected every second day (e.s.d). In the acute study, we found significant (p < 0.01) anti-seizure effects in animals treated with NRP2945 (20 µg/kg) and VPA, with NRP2945 slightly more efficacious, despite the 70,000 times lower molar dosage. In the chronic study, animals receiving 120 µg/kg/day and NRP 20 µg/kg e.s.d had significantly...Continue Reading

References

Jun 1, 1996·General Pharmacology·G De SarroE Gulletta
May 29, 1998·Progress in Neurobiology·L DanoberC Marescaux
Feb 5, 2000·The New England Journal of Medicine·P Kwan, M J Brodie
Nov 15, 2002·The European Journal of Neuroscience·Ghazal BanisadrStéphane Mélik Parsadaniantz
Jan 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tetsushi SadakataTeiichi Furuichi
Sep 2, 2004·Journal of Molecular Histology·Magda KuciaMariusz Z Ratajczak
Feb 10, 2006·The New England Journal of Medicine·Israel F Charo, Richard M Ransohoff
Jul 25, 2006·Experimental Cell Research·Thorsten GorbaFrank Sieg
Nov 18, 2008·Neurobiology of Disease·Nicola MarchiDamir Janigro
Nov 26, 2008·Nature Medicine·Paolo F FabeneGabriela Constantin
Dec 22, 2009·Journal of Neuroinflammation·Jieun ChoiSookyong Koh
Jun 15, 2010·Journal of Neuroimmunology·Paolo F FabeneGabriela Constantin
Jun 25, 2010·Reproductive Biomedicine Online·Ambika T SinghFrank Sieg
Dec 8, 2010·Nature Reviews. Neurology·Annamaria VezzaniTallie Z Baram
May 18, 2011·Neurobiology of Disease·Angelisa FrascaAnnamaria Vezzani
Feb 22, 2012·Science Translational Medicine·Elizabeth TringhamTerrance P Snutch
Jun 14, 2012·Epilepsia·Stefanie DedeurwaerdereTallie Z Baram
Jan 25, 2014·Lancet Neurology·Sophia VaradkarJ Helen Cross
Apr 2, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Nicolas CermakianSilke Kiessling

❮ Previous
Next ❯

Citations

Dec 20, 2019·Expert Opinion on Therapeutic Patents·Yesim A TahirovicLawrence J Wilson
Apr 3, 2021·European Journal of Pharmacology·Francesca LovisariMichele Simonato

❮ Previous
Next ❯

Software Mentioned

Spike
SpikeWave Finder
Compumedics
Graphpad Prism
and
Wave
Profusion

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.