Disease phenotype at diagnosis in pediatric Crohn's disease: 5-year analyses of the EUROKIDS Registry

Inflammatory Bowel Diseases
Charlotte I de BieEUROKIDS Porto IBD Working Group of ESPGHAN

Abstract

It has been speculated that pediatric Crohn's disease (CD) is a distinct disease entity, with probably different disease subtypes. We therefore aimed to accurately phenotype newly diagnosed pediatric CD by using the pediatric modification of the Montreal classification, the Paris classification. Information was collected from the EUROKIDS registry, a prospective, web-based registry of new-onset pediatric IBD patients in 17 European countries and Israel. When a complete diagnostic workup was performed (ileocolonoscopy, upper gastrointestinal [GI] endoscopy, small bowel imaging), CD patients were evaluated for ileocolonic disease extent, esophagogastroduodenal involvement, and jejunal/proximal ileal involvement. Disease behavior and the occurrence of granulomas were also analyzed. In all, 582 pediatric CD patients could be classified according to the Paris classification. Isolated terminal ileal disease (± limited cecal disease) was seen at presentation in 16%, isolated colonic disease in 27%, ileocolonic disease in 53%, and isolated upper GI disease in 4% of patients. In total, 30% had esophagogastroduodenal involvement and 24% jejunal/proximal ileal disease. Patients with L2 disease were less likely to have esophagogastroduoden...Continue Reading

References

Dec 31, 1997·Journal of Clinical Gastroenterology·H J Van KruiningenB J Freda
Jul 20, 2002·Inflammatory Bowel Diseases·Jacques CosnesJean-Pierre Gendre
Feb 27, 2003·Journal of Gastroenterology and Hepatology·Nopaorn PhavichitrAnthony G Catto-Smith
Oct 23, 2003·The Journal of Pediatrics·Subra KugathasanUNKNOWN Wisconsin Pediatric Inflammatory Bowel Disease Alliance
Nov 13, 2003·Archives of Disease in Childhood·A Sawczenko, B K Sandhu
Nov 19, 2003·European Journal of Gastroenterology & Hepatology·Margaret A StoneRichard Baker
Jun 24, 2005·Inflammatory Bowel Diseases·Ulrich MeinzerJean-Pierre Hugot
Jul 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·UNKNOWN IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition
Jan 28, 2006·World Journal of Gastroenterology : WJG·Annika Lapidus
Aug 15, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Linda Y TangCharles N Bernstein
Oct 24, 2006·Annals of the New York Academy of Sciences·Elisabet Gullberg, Johan D Söderholm
Jun 15, 2007·PloS One·Frédérick BarreauJean-Pierre Hugot
Nov 17, 2007·Alimentary Pharmacology & Therapeutics·S GuneshA B Hawthorne
Mar 28, 2008·Journal of Pediatric Gastroenterology and Nutrition·Vera De MatosDavid A Piccoli
Aug 12, 2008·Gastroenterology·Gwenola Vernier-MassouilleJean Frédéric Colombel
Aug 30, 2008·Gastroenterology·Johan Van LimbergenDavid C Wilson
Sep 18, 2008·The American Journal of Gastroenterology·Neera GuptaMelvin B Heyman
Nov 22, 2008·Inflammatory Bowel Diseases·David J KeljoJeffrey S Hyams
Feb 10, 2009·Inflammatory Bowel Diseases·Anders Paerregaard
May 11, 2010·Journal of Pediatric Gastroenterology and Nutrition·Jennifer L DotsonWallace Crandall
Jun 22, 2010·Inflammatory Bowel Diseases·Eric I BenchimolAnne M Griffiths
Jun 21, 2011·Inflammatory Bowel Diseases·Paul HendersonDavid C Wilson
Jul 12, 2011·Inflammatory Bowel Diseases·Pieta LehtinenAnssi Auvinen
Aug 23, 2011·Journal of Pediatric Gastroenterology and Nutrition·Charlotte I de BieUNKNOWN EUROKIDS Porto IBD Working Group of ESPGHAN

❮ Previous
Next ❯

Citations

Apr 20, 2013·World Journal of Gastroenterology : WJG·Barbara Dorottya LovaszPeter Laszlo Lakatos
Apr 4, 2014·World Journal of Gastroenterology : WJG·Petra A GolovicsPeter L Lakatos
Dec 7, 2013·European Journal of Pediatrics·Iva HojsakSanja Kolaček
May 29, 2014·Scandinavian Journal of Gastroenterology·Maja IdeströmYigael Finkel
Dec 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liza Vecchi BrumattiAnna Monica Bianco
Feb 20, 2016·Journal of Pediatric Surgery·Maria HukkinenKaija-Leena Kolho
Mar 7, 2014·Gastrointestinal Endoscopy·Jenifer R LightdaleUNKNOWN American Society for Gastrointestinal Endoscopy
Nov 7, 2015·Journal of Pediatric Gastroenterology and Nutrition·James J AshtonR Mark Beattie
Jul 25, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Eran IsraeliCharles N Bernstein
Apr 30, 2014·Gastroenterology Research and Practice·Katalin Eszter MüllerGabor Veres
Jul 19, 2015·Journal of Crohn's & Colitis·Peter L LakatosMaria Papp
Jul 15, 2015·Inflammatory Bowel Diseases·Dwight A WinterUNKNOWN Paediatric IBD Porto Group of ESPGHAN
Oct 22, 2013·Orvosi hetilap·Katalin Eszter MüllerGábor Veres
Feb 24, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Massimo MartinelliUNKNOWN IMIBD Group of the Italian Society for Paediatric Gastroenterology, Hepatology and Nutrition
May 28, 2016·Pediatric Radiology·Mary-Louise C Greer
Jun 21, 2016·Expert Review of Clinical Immunology·Kaija-Leena Kolho, Antti Ainamo
Apr 9, 2016·Inflammatory Bowel Diseases·Carmen S Horjus Talabur HorjePeter J Wahab
Sep 18, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Firas RinawiRaanan Shamir
Mar 28, 2017·Scandinavian Journal of Gastroenterology·Benjamin RothschildAmit Assa
Mar 8, 2017·Journal of Pediatric Gastroenterology and Nutrition·Jorge Amil-DiasUNKNOWN IBD Working Group of ESPGHAN (IBD Porto Group)
Apr 28, 2017·Alimentary Pharmacology & Therapeutics·A CoughlanUNKNOWN DOCHAS Study
May 27, 2017·Digestive Diseases and Sciences·Firas RinawiRaanan Shamir
Feb 3, 2016·Journal of Pediatric Gastroenterology and Nutrition·Elisabeth De GreefUNKNOWN IBD working group of BESPGHAN, BIRD
Jan 17, 2017·Pediatric Gastroenterology, Hepatology & Nutrition·Young Ah LeeJae Hong Park
May 11, 2017·Journal of Pediatric Gastroenterology and Nutrition·Sumit K SinghChandra M Pandey
Apr 1, 2017·Journal of Pediatric Gastroenterology and Nutrition·Amit AssaUNKNOWN ImageKids Study Group
Jun 13, 2017·Journal of Pediatric Gastroenterology and Nutrition·Annecarin BrücknerUNKNOWN CEDATA-GPGE study group
May 27, 2014·Inflammatory Bowel Diseases·Joanna LopezAshwin N Ananthakrishnan
Feb 27, 2014·Inflammatory Bowel Diseases·Marina AloiUNKNOWN SIGENP IBD Group
Dec 30, 2017·Journal of Pediatric Gastroenterology and Nutrition·Peter C ChurchUNKNOWN ImageKids Study group
Oct 19, 2013·Journal of Pediatric Gastroenterology and Nutrition·Darja UrlepRok Orel
Aug 19, 2014·World Journal of Gastroenterology : WJG·Luciana Rigoli, Rosario Alberto Caruso
Jul 25, 2019·Journal of Pediatric Gastroenterology and Nutrition·Christopher J BurgessDavid C Wilson
Dec 16, 2019·Pediatric Radiology·Elsa A van WassenaerBart G P Koot
Jul 4, 2013·Journal of Pediatric Gastroenterology and Nutrition·Katalin E MüllerUNKNOWN Hungarian IBD Registry Group (HUPIR)
Nov 16, 2013·Journal of Pediatric Gastroenterology and Nutrition·Arie LevineUNKNOWN European Society of Pediatric Gastroenterology, Hepatology, and Nutrition
Aug 17, 2020·European Journal of Gastroenterology & Hepatology·Anshu SrivastavaSurender Kumar Yachha
Jan 13, 2015·World Journal of Gastroenterology : WJG·Gian Eugenio TontiniHelmut Neumann
Jun 3, 2015·World Journal of Gastroenterology : WJG·Colin T Baillie, Jennifer A Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.