Disease presentation in relation to infection foci for non-pregnancy-associated human listeriosis in England and Wales, 2001 to 2007.

Journal of Clinical Microbiology
I A GillespieSarah J O'Brien

Abstract

Listeriosis is a rare but severe food-borne disease, affecting unborn or newly delivered infants, the elderly, and the immunocompromised. The epidemiology of listeriosis in England and Wales changed between 2001 and 2007, with more patients > or = 60 years old presenting with bacteremia (but without central nervous system [CNS] involvement). In order to explain this increase and understand the altered disease presentation, clinical, microbiological, and seasonal data on bacteremic cases of Listeria monocytogenes infection identified through national surveillance were compared with those for patients with CNS infections. Logistic regression analysis was applied while controlling for age. Bacteremic patients, who presented more frequently with gastrointestinal symptoms, were more likely to have underlying medical conditions than CNS patients. This was most marked in patients with malignancies, particularly digestive organ malignancies. Treatment to reduce stomach acid secretion modified the effect of nonmalignant underlying conditions on outcome, i.e., patients with an underlying condition who were not taking acid-suppressing medication were equally likely to have a bacteremic or a CNS infection. However, this type of therapy did...Continue Reading

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Citations

Mar 13, 2012·Epidemiology and Infection·P MookI A Gillespie
May 13, 2011·Foodborne Pathogens and Disease·Barbara M Lund, Sarah J O'Brien
May 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin J SilkBarbara E Mahon
Jan 5, 2011·Emerging Infectious Diseases·Piers MookIain A Gillespie
Mar 6, 2010·Interdisciplinary Perspectives on Infectious Diseases·Anna OevermannMarc Vandevelde
Jun 19, 2010·Wiener klinische Wochenschrift·Claudia MetelmannWerner Handrick
Jul 28, 2012·Scandinavian Journal of Gastroenterology·George D LiatsosAntonios Moulakakis
Feb 16, 2010·International Journal of Food Microbiology·Diane G NewellHilde Kruse
Mar 18, 2016·Emerging Infectious Diseases·Anne Kvistholm JensenEva Møller Nielsen
Mar 31, 2012·Virulence·Olivier Disson, Marc Lecuit
Jun 7, 2016·Lancet·Fiona McGillTom Solomon
Apr 1, 2017·Clinical Drug Investigation·Leon Fisher, Alexander Fisher
Aug 18, 2018·Oncology Nursing Forum·Ellen W Evans, Elizabeth C Redmond
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Jun 8, 2017·The Journal of Experimental Medicine·Simone BecattiniEric G Pamer
Apr 8, 2018·Clinical Medicine : Journal of the Royal College of Physicians of London·Michael J GriffithsTom Solomon
Mar 20, 2019·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·L PicardM Périvier
Jan 18, 2020·Microbiology Spectrum·Patrícia AntunesLuísa Peixe

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