Disease progression and survival in patients with prostate carcinoma and positive lymph nodes after radical retropubic prostatectomy

BJU International
Darko KroepflVirgilius Klevecka

Abstract

To determine disease progression and survival in patients with lymph node-positive prostate carcinoma after ascending radical retropubic prostatectomy (RP) and pelvic lymphadenectomy with different forms of postoperative adjuvant treatment. We analysed 82 patients with lymph node metastases at the time of surgery and who had a RP between 1993 and 2002. Data from clinical records and follow-up questionnaires were used. Overall survival, time to clinical disease progression and time to biochemical progression were used as endpoints to assess the outcome. Clinical progression was defined as documented local recurrence or distant metastases, and biochemical as an increase in prostate-specific antigen (PSA) of > or = 0.4 ng/mL. Variables analysed included PSA level, Gleason score before and after RP, clinical and pathological stage, number of positive lymph nodes and hormone therapy after RP. The statistical assessment included univariate regression analysis, and to analyse the distribution of clinical findings in different groups, Mantel-Haenszel statistics were used to test for differences in the numbers of patients. Survival and progression-free interval were assessed by Kaplan-Meier estimates and differences between groups calcu...Continue Reading

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Citations

Sep 17, 2010·Der Urologe. Ausg. A·A Heidenreich, A J Schrader
May 20, 2008·Lancet·Jan-Erik Damber, Gunnar Aus
Jun 26, 2007·Pathology International·Katia Ramos Moreira LeiteLuiz Heraldo Camara-Lopes
Sep 2, 2010·PloS One·Regina Berretta, Pablo Moscato
Jan 27, 2007·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Nebojsa JeremićVinka Maletić-Vuković
Jul 14, 2010·The Journal of Urology·Wayland HsiaoViraj A Master
Nov 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emmanuel S AntonarakisMario A Eisenberger

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