Disease progression and the risk factor analysis for chronic hepatitis C

Liver International : Official Journal of the International Association for the Study of the Liver
Dong Hyun SinnByung Chul Yoo

Abstract

The present study aimed to assess the incidence of advanced cirrhotic complications and to identify the risk factors associated with such complications in chronic hepatitis C. The data of 1137 chronic hepatitis C patients were retrospectively reviewed. We analysed the incidence rate and risk factors for 'disease progression', as defined by the occurrence of an increase of at least 2 points in the Child-Pugh score, oesophageal/gastric variceal bleeding, spontaneous bacterial peritonitis, hepatic encephalopathy, death related to liver disease or development of hepatocellular carcinoma (HCC). Of the 1137 patients enrolled for analysis, 490 patients received antiviral treatment. The overall annual incidence rate of disease progression was 0.8 and 3.7% for patients with and without antihepatitis C virus (anti-HCV) therapy respectively. The development of HCC was the most common cause of disease progression. In patients with anti-HCV therapy, treatment response, platelet level and aspartate aminotranferase:platelet ratio index (APRI) were independent factors associated with disease progression. For those without anti-HCV therapy, older age, male sex, diabetes, platelet level and APRI were independent factors for disease progression. ...Continue Reading

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Citations

Dec 14, 2011·Bone Marrow Transplantation·P LjungmanUNKNOWN Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation
Feb 22, 2011·Journal of Gastroenterology and Hepatology·Dong Hyun SinnSeung Woon Paik
Mar 18, 2011·World Journal of Gastroenterology : WJG·Takumi AkiyamaKazuma Fujimoto
Apr 20, 2013·World Journal of Gastroenterology : WJG·Dong Hyun SinnByung Chul Yoo
Dec 23, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Nima MahboobiSeyed Moayed Alavian
Mar 18, 2015·Journal of Gastroenterology and Hepatology·Sang Soo LeeChun Kang
Jun 11, 2015·Future Microbiology·Fabio Salvatore MacalusoAntonio Craxì
Apr 7, 2010·The Korean Journal of Hepatology·Young Suk Lim

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