PMID: 7542162Mar 1, 1995Paper

Disease progression in stage A prostate cancer

International Journal of Urology : Official Journal of the Japanese Urological Association
M AmakasuJ Shimazaki

Abstract

To study the disease progression in stage A prostate cancer, 212 patients with stage A from a group of 3370 patients who underwent transurethral resection of the prostate, or subcapsular prostatectomy during the period 1972-1991 were followed. The stage A cases were subdivided into 103 A1 patients and 109 A2 patients and their subsequent course was followed for an average of 41.7 months (6-174 months). Progression to clinical cancer was found in 12 patients, 2 from A1 and 10 from A2 groups. This progression was evident 40.5 months (14-130 months) after prostatectomy. Eight (67%) of these cases responded to endocrine therapy. The rate of expression of ras p21, and the number of argyrophilic nucleolar organizer regions in stage A cancer cells were greater in progressing than in non-progressing cases. These results indicate that stage A cancer with progression arises mainly from the A2 subgroup and exhibits a distinctly proliferative potential even at small foci.

References

Jan 1, 1992·The Prostate·J W MoulE H Chang
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·A B Hansen, B Ostergård
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H SumiyaJ Shimazaki
Jan 1, 1990·Japanese Journal of Cancer Research : Gann·Y NagataH Shiku
Dec 1, 1990·The American Journal of Surgical Pathology·J Deschênes, N Weidner
Mar 1, 1989·Japanese Journal of Cancer Research : Gann·H TsudaM Terada
Jun 1, 1989·Urology·I M Thompson, E J Zeidman
Mar 1, 1986·The American Journal of Surgical Pathology·G H MooreJ Murphy
Apr 1, 1986·British Journal of Urology·A AkdasD Remzi
Oct 1, 1986·The Journal of Urology·M L BluteG M Farrow
May 1, 1973·Journal of the National Cancer Institute·K Akazaki, G N Stemmerman
Jun 15, 1982·International Journal of Cancer. Journal International Du Cancer·R YataniP Correa
Aug 1, 1994·Japanese Journal of Cancer Research : Gann·H SuzukiJ Shimazaki
Aug 1, 1993·Japanese Journal of Cancer Research : Gann·S Broder

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