Disease-related determinants of quality of life 10 years after clinically isolated syndrome

International Journal of MS Care
R P KinkelXiaojun You

Abstract

The main clinical determinants of quality of life (QOL) 5 years after clinically isolated syndrome (CIS) are Expanded Disability Status Scale (EDSS) score and conversion to clinically definite multiple sclerosis (CDMS). The aim of this study was to determine the demographic, clinical, and magnetic resonance imaging (MRI) factors associated with QOL 10 years after CIS. Controlled High Risk Avonex® Multiple Sclerosis Prevention Study in Ongoing Neurologic Surveillance (CHAMPIONS) 10-year patients were assessed for CDMS, EDSS score, MRI T2 activity, brain parenchymal fraction, and patient-reported QOL. Associations were evaluated using analysis of variance models. A second clinical event consistent with CDMS and higher EDSS scores at years 5 and 10 were associated with lower 36-item Short Form Health Status Survey (SF-36) Physical Component Summary scores at year 10 (P < .01). Patients with earlier onset of CDMS had worse patient-reported Physical Component Summary, SF-36 Mental Component Summary, fatigue, and pain scores at year 10 than patients with later or no onset of CDMS. Neither initial randomization group nor any MRI metrics assessed at baseline or during follow-up were associated with QOL at 10 years. These results suppor...Continue Reading

Associated Clinical Trials

References

May 1, 1996·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D G BrunetT A MacKenzie
Dec 22, 2000·Spine·J E Ware
May 30, 2001·Lancet·G ComiUNKNOWN Early Treatment of Multiple Sclerosis Study Group
Nov 13, 2002·Neurology·E FisherN A Simonian
Jan 27, 2006·Neurology·R Philip KinkelUNKNOWN CHAMPIONS Study Group
Aug 19, 2007·Annals of Neurology·Richard A RudickUNKNOWN AFFIRM and SENTINEL Investigators
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Jan 24, 2012·Lancet Neurology·David H MillerOlga Ciccarelli

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Citations

Sep 16, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Cindy J NowinskiDavid Cella
Jul 15, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·B NourbakhshE Waubant
Dec 2, 2020·BMJ Open·Irene Gil-GonzálezMaría Ángeles Pérez-San-Gregorio
Feb 3, 2021·The International Journal of Neuroscience·Triantafyllos DoskasΚonstantinos Vadikolias

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