Disease-related differences in resting-state networks: a comparison between localized provoked vulvodynia, irritable bowel syndrome, and healthy control subjects

Pain
Arpana GuptaJennifer Labus

Abstract

Localized provoked vulvodynia (LPVD) affects approximately 16% of the female population, but biological mechanisms underlying symptoms remain unknown. Like in other often comorbid chronic pain disorders, altered sensory processing and modulation of pain, including central sensitization, dysregulation of endogenous pain modulatory systems, and attentional enhancement of pain perception, have been implicated. The aim of this study was to test whether regions of interest showing differences in LPVD compared to healthy control subjects (HCs) in structural and evoked-pain neuroimaging studies, also show alterations during rest when compared with HCs and a chronic pain control group (irritable bowel syndrome [IBS]). Functional magnetic resonance imaging was performed during resting state in 87 age-matched premenopausal females (29 LPVD, 29 HCs, and 29 IBS). Group-independent component analysis and general linear models were applied to investigate group differences in the intrinsic connectivity of regions comprising sensorimotor, salience, and default mode resting-state networks. Subjects with LPVD showed substantial alterations in the intrinsic connectivity of these networks compared with HCs and IBS. The intrinsic connectivity of ma...Continue Reading

References

Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Nov 1, 1995·Neural Computation·A J Bell, T J Sejnowski
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Jan 5, 2002·The American Journal of Gastroenterology·L ChangE A Mayer
May 9, 2002·Journal of Sex & Marital Therapy·Sophie BergeronSamir Khalifé
Jun 6, 2003·The British Journal of Dermatology·P TympanidisP Dowd
Nov 19, 2003·Current Opinion in Obstetrics & Gynecology·Olivia C Smart, Allan B MacLean
Nov 16, 2004·Gynecologic and Obstetric Investigation·Reuvit HalperinDavid Schneider
Apr 20, 2005·Pain·Caroline F PukallM Catherine Bushnell
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christian F BeckmannStephen M Smith
Mar 2, 2006·Obstetrics and Gynecology·Lauren D ArnoldGeorge G Rhoads
May 9, 2006·Gastroenterology·Douglas A Drossman
Sep 20, 2006·Applied Psychophysiology and Biofeedback·Howard I Glazer, Carolyn D Laine
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Aug 7, 2007·Neuron·Irene Tracey, Patrick W Mantyh
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marwan N BalikiDante R Chialvo
May 10, 2008·Neuron·Maurizio CorbettaGordon L Shulman
Jul 9, 2008·Current Opinion in Neurology·Michael Greicius
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Oct 22, 2008·Pain·P SchweinhardtM C Bushnell
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephen M SmithChristian F Beckmann
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marc Guitart-MasipEmrah Düzel
Apr 21, 2010·IEEE Transactions on Bio-medical Engineering·Patrick C H Ma, Keith C C Chan
Apr 29, 2010·Current Pain and Headache Reports·Michael C Lee, Irene Tracey
May 28, 2010·Arthritis and Rheumatism·Vitaly NapadowRichard E Harris
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Oct 27, 2010·International Urogynecology Journal·Renee BassalyStuart Hart
May 18, 2011·The Journal of Urology·A SchrumJ P Kuhtz-Buschbeck
Jul 29, 2011·Obstetrical & Gynecological Survey·Jeffrey C Andrews
Sep 9, 2011·IEEE Transactions on Bio-medical Engineering·Sai MaTülay Adalı
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marwan N BalikiA Vania Apkarian
Oct 4, 2011·American Journal of Obstetrics and Gynecology·Barbara Diane ReedHope Katharine Haefner
Dec 2, 2011·Annual Review of Psychology·Mohammed R Milad, Gregory J Quirk
Apr 17, 2012·The Journal of Urology·M P FitzGeraldUNKNOWN Interstitial Cystitis Collaborative Research Network
Apr 25, 2012·Annual Review of Neuroscience·Steven E Petersen, Michael I Posner
May 15, 2012·Neuroscience Letters·Melissa A FarmerA Vania Apkarian
Aug 17, 2012·Journal of Psychiatry & Neuroscience : JPN·Alexander OttiMichael Noll-Hussong
Aug 24, 2012·Obstetrics and Gynecology·Barbara D ReedHope K Haefner
Sep 11, 2012·The Journal of Pain : Official Journal of the American Pain Society·Denniz ZolnounWilliam Maixner

❮ Previous
Next ❯

Citations

Dec 15, 2015·CNS Neuroscience & Therapeutics·Rachel D MoloneyJohn F Cryan
Mar 6, 2016·The Journal of Sexual Medicine·Caroline F PukallGloria Bachmann
Dec 17, 2015·Brain Structure & Function·Kasey S HemingtonKaren D Davis
Aug 21, 2015·The Journal of Pain : Official Journal of the American Pain Society·Deepika S DarbariRichard E Harris
Aug 8, 2015·Neuron·Marwan N Baliki, A Vania Apkarian
Mar 4, 2017·Journal of Neurogastroenterology and Motility·In-Seon LeePaul Enck
Apr 14, 2018·Women's Health·Rosemary Basson, Thea Gilks
Jan 24, 2018·Pain Research and Treatment·Maria Beatrice PassavantiMaria Caterina Pace
Dec 5, 2015·Molecular Neurobiology·Rongfeng QiGuang Ming Lu
Jun 7, 2019·BMC Urology·Su Jin KimHana Yoon
Aug 30, 2018·Scientific Reports·Lin-Chien LeeJen-Chuen Hsieh
May 2, 2020·Nature Reviews. Disease Primers·Sophie BergeronNina Bohm-Starke
Nov 22, 2016·Journal of Neuroscience Research·Arpana GuptaLisa A Kilpatrick
Jul 18, 2020·The Journal of Pain : Official Journal of the American Pain Society·Lydia LoAndrea Rapkin
May 25, 2021·The Journal of Pain : Official Journal of the American Pain Society·Jennifer S LabusAndrea Rapkin
Aug 12, 2021·Scandinavian Journal of Pain·Sin Ki NgBernadette M Fitzgibbon
Aug 22, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Ying WangDeepika S Darbari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Imaging of Neural Circuits

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.

Brain Imaging of Neural Circuits (MDS)

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.

Related Papers

The Journal of Pain : Official Journal of the American Pain Society
Jennifer KornelsenBoguslaw Tomanek
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jui-Yang HongEmeran A Mayer
The Journal of Pain : Official Journal of the American Pain Society
Anne BolwerkChristian Maihöfner
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jui-Yang HongEmeran A Mayer
© 2022 Meta ULC. All rights reserved