Disease severity and therapy as predictors of cardiovascular risk in psoriasis: a population-based cohort study.

Journal of the European Academy of Dermatology and Venereology : JEADV
H Maradit-KremersM T McEvoy

Abstract

Previous studies suggest an increased risk of cardiovascular disease in psoriasis, but the relative contributions of traditional risk factors and markers of disease severity are unclear. We examined the effect of psoriasis disease characteristics on cardiovascular risk after adjusting for traditional cardiovascular risk factors. Study populations included (a) case-cohort sample of 771 patients nested within a population-based psoriasis incidence cohort, and (b) cohort of 1905 patients with incident and prevalent psoriasis patients. Both cohorts were followed-up to ascertain disease and treatment characteristics, traditional cardiovascular risk factors and cardiovascular outcomes. Cox proportional hazards regression models were used to identify predictors of cardiovascular outcomes. After adjusting for traditional risk factors, increasing number of psoriasis-affected body sites at disease onset (HR: 1.53 per additional site, 95% CI: 1.20, 1.95) was significantly associated with an increased risk of cardiovascular outcomes. Phototherapy (HR: 3.76, 95% CI: 2.45, 5.77) and systemic therapy (HR: 2.17, 95% CI: 1.50, 3.13) were associated with a higher risk of cardiovascular outcomes in univariate analyses, but these relatively strong...Continue Reading

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Citations

Oct 2, 2013·Dermatology Research and Practice·Spyridoula DoukakiMaria Rita Bongiorno
May 3, 2016·International Journal of Clinical Rheumatology·Alexis Ogdie, Lihi Eder
Aug 1, 2012·Journal of the American Academy of Dermatology·Howa YeungJoel M Gelfand
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