Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-gamma-secreting cells in the peripheral blood

Arthritis and Rheumatism
E HagiwaraD K Klinman

Abstract

To compare the phenotype and frequency of cells that actively secrete type 1 and type 2 cytokines in systemic lupus erythematosus (SLE) patients (n = 46), versus normal controls (n = 60). ELISPOT analysis of freshly isolated peripheral blood mononuclear cells (PBMC). T cells were the major source of interleukin-2 (IL-2), IL-4, and interferon gamma (IFN gamma), whereas monocytes were the primary source of IL-6 and IL-10 in the PB of lupus patients. Significantly fewer PBMC spontaneously secreted IFN gamma and IL-2 (P > or = 0.03), while significantly more PBMC produced IL-6 and IL-10 (P < 0.001), in lupus patients versus controls. Disease severity in lupus patients correlated with an elevated ratio of IL-1O:IFN gamma-secreting cells (P < 0.001). SLE is characterized by an imbalance in the ratio of type 1:type 2 cytokine-secreting PBMC.

References

Oct 1, 1992·Clinical and Experimental Immunology·P E SpronkC G Kallenberg
Apr 1, 1992·Clinical Immunology and Immunopathology·M Linker-Israeli
Jul 1, 1992·Clinical and Experimental Immunology·N OgawaY Goto
Aug 1, 1991·Immunology Today·S Romagnani
Oct 1, 1991·Annals of Internal Medicine·A D SteinbergA M Krieg
Dec 1, 1990·Immunological Reviews·A D SteinbergD M Klinman
Jan 1, 1990·Autoimmunity·J Watson, E S Wijelath
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Jun 1, 1982·The Journal of Clinical Investigation·J Alcocer-Varela, D Alarcón-Segovia
Jan 1, 1981·International Archives of Allergy and Applied Immunology·T M BeckerA D Steinberg
Jan 1, 1995·AIDS Research and Human Retroviruses·D M KlinmanJ Conover
Jan 1, 1994·Annual Review of Immunology·S Romagnani
Jan 1, 1993·Journal of Clinical Immunology·M al-JanadiS Raziuddin

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Citations

Apr 16, 2002·Arthritis and Rheumatism·Andrea DoriaPier Franca Gambari
Mar 29, 2001·Journal of Neuroscience Research·M TomitaT J Santoro
Jan 1, 1997·Springer Seminars in Immunopathology·D M KlinmanJ Conover
Aug 3, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Yi LiWestley H Reeves
Feb 19, 2008·Inflammation·Suleyman Serdar KocaKader Aksoy
Oct 6, 2010·Journal of Clinical Immunology·Aharon KesselElias Toubi
Jun 7, 2003·Journal of Autoimmunity·Luis Llorente, Yvonne Richaud-Patin
Dec 1, 1996·Current Opinion in Immunology·F M Brennan, M Feldmann
Apr 20, 2000·Transfusion Science·A H LazarusJ Freedman
Jan 20, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I LalaniA R Ahmed
Sep 11, 2002·Cytokine & Growth Factor Reviews·Amy M BeebeRene de Waal Malefyt
Feb 14, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Takashi KuroiwaDimitrios T Boumpas
Jun 16, 2001·International Immunopharmacology·D Verthelyi
Jan 22, 2008·Expert Reviews in Molecular Medicine·Meera Ramanujam, Anne Davidson
Mar 5, 2013·Cellular & Molecular Immunology·Vera Sau-Fong ChanChak-Sing Lau
Nov 10, 2010·Nature Reviews. Rheumatology·Yun Deng, Betty P Tsao
Aug 14, 1999·Immunology·B J RipleyD S Latchman
Oct 3, 2000·Thyroid : Official Journal of the American Thyroid Association·B M JonesA W Kung
Aug 23, 2002·Current Opinion in Rheumatology·Bryan D Gescuk, John C Davis
Sep 29, 2011·Annals of the Rheumatic Diseases·Sander I van LeuvenAmy S Major
Apr 15, 2005·Annals of the Rheumatic Diseases·M AlekszaK Dankó

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