Disease-Specific Effects of Matrix and Growth Factors on Adhesion and Migration of Rheumatoid Synovial Fibroblasts

The Journal of Immunology : Official Journal of the American Association of Immunologists
Stephanie LefèvreElena Neumann

Abstract

In rheumatoid arthritis (RA), cartilage and bone matrix are degraded, and extracellular matrix (ECM) proteins, acting as cellular activators, are liberated. Similar to ECM proteins, matrix-bound chemokines, cytokines, and growth factors (GFs) influence functional properties of key cells in RA, especially synovial fibroblasts. The role of these molecules on attachment, migration, and proinflammatory and prodestructive activation of RASFs was analyzed. Adhesion/migration of RASFs were examined under GF-enriched (GF+) or -reduced (GF-) conditions with or without addition of matrix-associated GFs, TGF-β, and platelet-derived GF to GF- or culture supernatants. Fibroblast adhesion and alterations in proinflammatory/prodestructive properties (e.g., IL-6/matrix metalloproteinase 3-release) in response to matrix-associated molecules were compared. Effects of GF+, GF-, and other ECM components on human RASF-mediated cartilage invasion were examined in the SCID mouse model. RASF adhesion under GF- conditions was significantly lower compared with GF+ conditions (6.8- versus 8.3-fold). This effect was specific for RA because control cells showed opposite effects (e.g., osteoarthritis synovial fibroblasts [SF]; GF- versus GF+: 10.7- versus 8...Continue Reading

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Citations

Sep 13, 2017·International Reviews of Immunology·Scott Le RossignolNagaraja Haleagrahara
Jul 6, 2018·Zeitschrift für Rheumatologie·E NeumannU Müller-Ladner
Jan 9, 2019·Nature Reviews. Rheumatology·Feini QuRobert L Mauck
Mar 3, 2019·Nature Reviews. Rheumatology·Oore-Ofe Olumuyiwa-AkeredoluEtheresia Pretorius
Jun 4, 2020·International Journal of Molecular Sciences·Ute NazetChristian Kirschneck
Nov 30, 2019·Cellular Signalling·A Sainio, H Järveläinen
Apr 10, 2019·Current Rheumatology Reviews·Yulia V PolyakovaIrina A Zborovskaya

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