Disease-specific gait deviations in pediatric patients with X-linked hypophosphatemia.

Gait & Posture
Gabriel T MindlerAdalbert Raimann

Abstract

X-linked hypophosphatemia (XLH) represents the most common genetic form of rickets featuring profound hypophosphatemia with associated skeletal and non-skeletal manifestations. Early onset gait disturbances contribute strongly to the burden of disease. However, no study has comprehensively characterized naturally occurring gait deviations in pediatric patients with XLH. Can disease-specific gait deviations and potentially influencing factors be identified by gait analysis in non-surgically treated children with XLH? Gait laboratory assessments of 12 pediatric patients with XLH without previous long bone surgery was retrospectively analyzed and compared to age-matched healthy controls. Radiologic and clinical parameters of XLH patients were correlated with kinematic gait variables and gait scores. Reduced external knee rotation and increased external hip orientation was ubiquitous in children with XLH. Increased lateral trunk lean, or "waddling gait", occurred in five children and was associated with varus knee deformities. Overall, children with XLH showed a reduced Gait Deviation Index (GDI) compared to controls. Radiologic and gait analysis revealed complex combined frontal and torsional deformity of the lower limbs as a comm...Continue Reading

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Citations

Jan 30, 2021·Wiener medizinische Wochenschrift·Gabriel T MindlerRudolf Ganger
Apr 6, 2021·Frontiers in Endocrinology·Michaël R LaurentJohan Vande Walle

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