Diseases of renal adenosine triphosphatase

The American Journal of the Medical Sciences
S Eiam-OngN A Kurtzman


Most renal transport is a primary or secondary result of the action of one of three membrane bound ion translocating ATPase pumps. The proximal tubule mechanisms for the reabsorption of salt, volume, organic compounds, phosphate, and most bicarbonate reabsorption depend upon the generation and maintenance of a low intracellular sodium concentration by the basolateral membrane Na-K-ATPase pump. The reabsorption of fluid and salt in the loop of Henle is similarly dependent on the energy provided by Na-K-ATPase activity. Some proximal tubule bicarbonate reabsorption and all distal nephron proton excretion is a product of one of two proton translocating ATPase pumps, either an electrogenic H-ATPase or an electroneutral H-K-ATPase. In this article, the authors review the biochemistry and physiology of pump activity and consider the pathophysiology of proximal and distal renal tubular acidosis, the Fanconi syndrome, and Bartter's syndrome as disorders of ATPase pump function.


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Related Concepts

Fanconi Anemia
Adenosine Triphosphatases
De Toni-Debre-Fanconi Syndrome
Organic Chemicals
Loop of Henle
Renal Tubular Acidosis
Renal Tubular Acidosis, Type II
Distal Renal Tubular Acidosis
Renal Tubule Structure

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