Diseases originate and terminate by genes: unraveling nonviral gene delivery

Drug Delivery and Translational Research
Rajan SwamiSistla Ramakrishna

Abstract

The world is driving in to the era of transformation of chemical therapeutic molecules to biological genetic material therapeutics, and that is where the biological drugs especially "genes" come into existence. These genes worked as "magical bullets" to specifically silence faulty genes responsible for progression of diseases. Viral gene delivery research is far ahead of nonviral gene delivery technique. However, with more advancement in polymer science, new ways are opening for better and efficient nonviral gene delivery. But efficient delivery method is always considered as a bottleneck for gene delivery as success of which will decide the fate of gene in cells. During the past decade, it became evident that extracellular as well as intracellular barriers compromise the transfection efficiency of nonviral vectors. The challenge for gene therapy research is to pinpoint the rate-limiting steps in this complex process and implement strategies to overcome the biological physiochemical and metabolic barriers encountered during targeting. The synergy between studies that investigate the mechanism of breaking in and breaking out of nonviral gene delivery carrier through various extracellular and intracellular barriers with desired c...Continue Reading

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Oct 28, 2014·Luminescence : the Journal of Biological and Chemical Luminescence·Jitendra WaghHemant P Soni
Mar 31, 2015·Chemistry and Physics of Lipids·Indu SinghRamakrishna Sistla
Mar 7, 2020·Bioengineered·Khalisanni KhalidLai Chin Wei
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Rajan SwamiSanyog Jain

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