Disentangling the prefrontal network for rule selection by means of a non-verbal variant of the Wisconsin Card Sorting Test.

Human Brain Mapping
Karsten SpechtGereon R Fink

Abstract

This study disentangles the prefrontal network underlying executive functions involved in the Wisconsin Card Sorting Test (WCST). During the WCST, subjects have to perform two key processes: first, they have to derive the correct sorting rule for each trial by trial-and-error, and, second, they have to detect when this sorting rule is changed by the investigator. Both cognitive processes constitute key components of the executive system, which is subserved by the prefrontal cortex. For the current fMRI experiment, we developed a non-verbal variant of the WCST. Subjects were instructed either to respond according to a given sorting rule or to detect the correct sorting rule, like in the original version of the WCST. Data were obtained from 14 healthy male volunteers and analysed using SPM and a random effects model. All conditions activated a fronto-parietal network, which was generally more active when subjects had to search for the correct sorting rule than when the rule was announced beforehand. Significant differences between these two conditions were seen in the dorsolateral prefrontal cortex (PFC) and the parietal lobe. In addition, the data provided new evidence for the assumption of differentiated roles of the left and r...Continue Reading

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Citations

Mar 31, 2010·Journal of Cognitive Neuroscience·Seiki KonishiYasushi Miyashita
Oct 2, 2015·Annals of the New York Academy of Sciences·Benjamin O TurnerMichael B Miller
Jul 30, 2010·Kidney International·Silke LuxFrank Eitner
Apr 13, 2012·Brain and Language·Kristiina KompusRené Westerhausen
Oct 27, 2015·Frontiers in Systems Neuroscience·Jean-Sebastien ProvostOury Monchi
Aug 25, 2015·Frontiers in Human Neuroscience·Kenneth HugdahlKarsten Specht
Sep 28, 2010·NeuroImage·Frank Van Overwalle
Sep 18, 2014·Frontiers in Behavioral Neuroscience·Annick N TanguayMark B Ferland
Jan 23, 2018·Scandinavian Journal of Psychology·Karsten Specht, Philip Wigglesworth
Nov 3, 2020·Journal of Cognitive Neuroscience·Antonino Vallesi
Mar 24, 2021·Behavior Research Methods·Stephanie MilesAndrea Phillipou
Oct 13, 2021·Human Brain Mapping·Nils C J MüllerGuillén Fernández

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