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Disentangling the roles of natural selection and genetic drift in shaping variation at MHC immunity genes

Molecular Ecology

Oct 11, 2011

Jolene T SuttonIan G Jamieson

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Abstract

The major histocompatibility complex (MHC) forms an integral component of the vertebrate immune response and, due to strong selection pressures, is one of the most polymorphic regions of the entire genome. Despite over 15 years of research, empirical studies offer highly contradictory e...read more

Mentioned in this Paper

Genetic Drift
Genetics, Population
Major Histocompatibility Complex
Evolution, Neutral
Genetic Polymorphism
Biological Evolution
Selection, Genetic
Major Histocompatibility Complex Location
Variation (Genetics)
Paper Details
References
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  • Citations71
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  • References47
  • Citations71
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Disentangling the roles of natural selection and genetic drift in shaping variation at MHC immunity genes

Molecular Ecology

Oct 11, 2011

Jolene T SuttonIan G Jamieson

PMID: 21981032

DOI: 10.1111/j.1365-294x.2011.05292.x

Abstract

The major histocompatibility complex (MHC) forms an integral component of the vertebrate immune response and, due to strong selection pressures, is one of the most polymorphic regions of the entire genome. Despite over 15 years of research, empirical studies offer highly contradictory e...read more

Mentioned in this Paper

Genetic Drift
Genetics, Population
Major Histocompatibility Complex
Evolution, Neutral
Genetic Polymorphism
Biological Evolution
Selection, Genetic
Major Histocompatibility Complex Location
Variation (Genetics)

Feeds With Similar Papers

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Related Papers

Paper Details
References
  • References47
  • Citations71
12345
  • References47
  • Citations71
12345...

Download from

Publisher
PubMed
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