Abstract
To explore the heterogeneity of Tourette syndrome as part of a neurodevelopmental spectrum. Using hierarchical ascendant clustering based on tic symptoms, developmental milestones, and neurodevelopmental comorbidities, we analyzed the heterogeneity of Tourette syndrome phenotypes in a sample of 174 children and adolescents with Tourette syndrome referred to a tertiary university clinic. The model yielded three distinct clusters characterized as follows. In cluster 1, we found many neurodevelopmental comorbidities (including intellectual disabilities, autism spectrum disorder, attention-deficit-hyperactivity disorder [ADHD], and learning disabilities) and academic impairments. In cluster 2, patients had no other neurodevelopmental comorbidities. In cluster 3, patients had higher intelligence, a high frequency of attentional impairment, school problems related to both ADHD and unspecific attention difficulties, and handwriting problems related to the tics themselves. Interestingly, clusters did not differ in terms of family history or anxious-depressive comorbidities. The only other differences that emerged were related to prenatal or perinatal risk factors (more represented in cluster 1) and treatment profiles (higher rates of s...Continue Reading
References
Jul 1, 1992·Journal of Child Psychology and Psychiatry, and Allied Disciplines·L HendersonS Henderson
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Jul 1, 1989·Journal of the American Academy of Child and Adolescent Psychiatry·J F LeckmanD J Cohen
Oct 1, 1994·Journal of Autism and Developmental Disorders·C LordA Le Couteur
Dec 1, 1993·Journal of Learning Disabilities·L Hamstra-Bletz, A W Blöte
May 1, 1997·Neurologic Clinics·L E Packer
Jul 2, 1999·Neuropsychologia·T ManlyK Hawkins
Feb 2, 2002·The American Journal of Psychiatry·John P Alsobrook, David L Pauls
Oct 1, 1964·Perceptual and Motor Skills·P MASLOWJ R WHITTLESEY
Mar 16, 2004·Acta Neurologica Scandinavica·V EapenM Robertson
Apr 4, 2006·Biological Psychiatry·Carol A MathewsVictor I Reus
Dec 8, 2006·Psychiatry Research·Eric A StorchWayne K Goodman
Mar 25, 2008·Biological Psychiatry·Marco A GradosUNKNOWN Tourette Syndrome Association International Consortium for Genetics
Aug 14, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Mary M RobertsonDavid L Pauls
Mar 27, 2009·Journal of Developmental and Behavioral Pediatrics : JDBP·Tamara PringsheimPaul O'Connor
Jul 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Daniel A GormanBradley S Peterson
Mar 26, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Andrea E CavannaMary M Robertson
Apr 27, 2011·Journal of Autism and Developmental Disorders·David GrodbergJoseph D Buxbaum
Oct 23, 2013·Psychiatry Research·Joseph F McGuireLawrence Scahill
Jan 15, 2014·Molecular Autism·Holly N CukierMargaret A Pericak-Vance
Jan 21, 2015·Brain Connectivity·Janet K KernMark R Geier
Jul 15, 2015·The Australian and New Zealand Journal of Psychiatry·Valsamma EapenPerminder Sachdev
Feb 2, 2016·Psychiatry Research·Hilde M Huisman-van DijkDaniëlle C Cath
Aug 6, 2016·Journal of Psychiatric Research·Mohamed AbdulkadirAndrea Dietrich
Nov 5, 2016·The American Journal of Psychiatry·Sabrina M DarrowUNKNOWN Tourette Syndrome Association International Consortium for Genetics
Jun 28, 2017·Psychological Medicine·M E HirschtrittC A Mathews