PMID: 9185147Jul 1, 1997Paper

Disequilibria in the distribution of rpoB alleles in rifampicin-resistant M. tuberculosis isolates from Germany and Sierra Leone

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
H RinderT Löscher

Abstract

The effectiveness of culture-independent resistance predictions by molecular techniques is dependent on the number and the frequency of accessible resistance-associated genomic mutations. We have characterized an rpoB gene region involved in rifampicin resistance in 49 Mycobacterium tuberculosis isolates resistant to rifampicin from Germany and Sierra Leone. The determined frequencies of mutations differed between both countries of origins as well as with respect to previously reported distributions of resistance mutations. It is concluded that at least for some isolates the acquisition of mutations leading to rifampicin resistance in clinical samples of M. tuberculosis is a non-random process which may lead to a geographical and temporal dependence of the sensitivities of molecular typing techniques for rifampicin resistance predictions.

References

Oct 1, 1994·Antimicrobial Agents and Chemotherapy·D L WilliamsT P Gillis
Aug 1, 1993·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·P Godfrey-FaussettL Clancy
Jan 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·D A CaugantT Tønjum

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Citations

May 25, 2005·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Elif AktasZhenhua Yang
Jul 7, 2009·The Journal of Antimicrobial Chemotherapy·Indra L BergvalRichard M Anthony
Dec 14, 2007·Journal of Clinical Microbiology·I L BergvalR M Anthony
Jan 20, 2004·Journal of Medical Microbiology·Srinivas V RamaswamyEdward A Graviss
Mar 13, 1999·Journal of Clinical Microbiology·G PozziG Orefici

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