Disinhibition combines with excitation to extend the operating range of the OFF visual pathway in daylight.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Michael B ManookinJonathan B Demb

Abstract

Cone signals divide into parallel ON and OFF bipolar cell pathways, which respond to objects brighter or darker than the background and release glutamate onto the corresponding type of ganglion cell. It is assumed that ganglion cell excitatory responses are driven by these bipolar cell synapses. Here, we report an additional mechanism: OFF ganglion cells were driven in part by the removal of synaptic inhibition (disinhibition). The disinhibition played a relatively large role in driving responses at low contrasts. The disinhibition persisted in the presence of CNQX and d-AP-5. Furthermore, the CNQX/d-AP-5-resistant response was blocked by l-AP-4, meclofenamic acid, quinine, or strychnine but not by bicuculline. Thus, the disinhibition circuit was driven by the ON pathway and required gap junctions and glycine receptors but not ionotropic glutamate or GABA(A) receptors. These properties implicate the AII amacrine cell, better known for its role in rod vision, as a critical circuit element through the following pathway: cone --> ON cone bipolar cell --> AII cell --> OFF ganglion cell. Rods could also drive this circuit through their gap junctions with cones. Thus, to light decrement, AII cells, driven by electrical synapses with ...Continue Reading

References

Mar 1, 1992·Trends in Neurosciences·P H Schiller
Nov 8, 1992·The Journal of Comparative Neurology·E StrettoiR F Dacheux
Dec 29, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E Cohen, P Sterling
Aug 1, 1989·The Journal of Comparative Neurology·L Peichl
Feb 1, 1989·The Journal of Comparative Neurology·F R AmthorC W Oyster
Oct 4, 1974·Science·H Kolb, E V Famiglietti
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·S H DeVries, D A Baylor
Nov 1, 1994·Neuron·P RöhlichA Szél
Jun 22, 1993·The Journal of Comparative Neurology·M H ChunH Wässle
Jan 1, 1997·Spatial Vision·D H Brainard
Nov 5, 1998·The Journal of Comparative Neurology·N MengerH Wässle
Oct 26, 1999·Progress in Retinal and Eye Research·D M Dacey
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·I HackJ H Brandstätter
Apr 5, 2001·Progress in Retinal and Eye Research·S A Bloomfield, R F Dacheux
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M SrinivasD C Spray
Oct 7, 2003·The Journal of Comparative Neurology·Eun-Jin LeeMyung-Hoon Chun
Dec 6, 2003·The European Journal of Neuroscience·Eun-Jin LeeMyung-Hoon Chun
May 25, 2004·The Journal of Comparative Neurology·Wei LiStephen C Massey
Nov 5, 2004·Journal of Neurophysiology·E Brady TrexlerStephen C Massey
Dec 15, 2004·Visual Neuroscience·Michael KalloniatisHeinz Wässle
Mar 26, 2005·The Journal of Comparative Neurology·Timm SchubertReto Weiler
Jul 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bin LinRichard H Masland
Sep 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yi Han, Stephen C Massey
Sep 22, 2005·The Journal of Comparative Neurology·Béla VölgyiStewart A Bloomfield
Oct 11, 2005·Visual Neuroscience·Elizabeth S YamadaDavid W Marshak
Apr 7, 2006·Visual Neuroscience·Olivia N DumitrescuHeinz Wässle

❮ Previous
Next ❯

Citations

Jul 29, 2009·Journal of Computational Neuroscience·Alyosha MolnarFrank S Werblin
May 14, 2009·Visual Neuroscience·Kathryn E KlumpDavid W Marshak
Jul 16, 2009·Visual Neuroscience·Michiel van WykW Rowland Taylor
Oct 12, 2010·Visual Neuroscience·Erika D Eggers, Peter D Lukasiewicz
Aug 26, 2011·Visual Neuroscience·William N GrimesJeffrey S Diamond
Feb 9, 2012·Visual Neuroscience·Jonathan B Demb, Joshua H Singer
Feb 9, 2012·Visual Neuroscience·Chi Zhang, Maureen A McCall
May 29, 2012·Nature Neuroscience·Alexander Sher, Steven H DeVries
Oct 28, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mihai Manu, Stephen A Baccus
Jun 4, 2013·Annual Review of Neuroscience·Pablo D Jadzinsky, Stephen A Baccus
Dec 30, 2011·Journal of Neurophysiology·Ilya BuldyrevW Rowland Taylor
Mar 22, 2013·PLoS Computational Biology·Syed Y AbbasDiana L Pettit
Jan 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin T BeierConstance L Cepko
Aug 5, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel A ButtsLiam Paninski
May 27, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yanbin V WangJonathan B Demb
Sep 13, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zachary NicholsJonathan Victor
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joanna D CrookDennis M Dacey
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bart G BorghuisJonathan B Demb
Sep 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maureen E EstevezDavid M Berson
Oct 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chaowen WuZhuo-Hua Pan
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sowmya Venkataramani, W Rowland Taylor
Aug 26, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gabe J Murphy, Fred Rieke
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·W Wade KothmannJohn O'Brien
Jan 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric Y ChenMichael J Berry
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joanna D CrookDennis M Dacey
Apr 23, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhiyin Liang, Michael A Freed
Apr 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jon Cafaro, Fred Rieke
Mar 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bart G BorghuisRobert G Smith
Mar 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Regina D NoblesMaureen A McCall
May 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David J MargolisPeter B Detwiler
May 8, 2014·Visual Neuroscience·Joanna D CrookDennis M Dacey
Jun 24, 2014·Current Opinion in Neurobiology·John O'Brien
Dec 4, 2013·The Journal of Physiology·Michael A Freed, Zhiyin Liang
Oct 27, 2010·The Journal of Physiology·Yunbo Song, Malcolm M Slaughter
Sep 18, 2013·The Journal of Physiology·D A ProttiS G Solomon
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ji-Jie PangSamuel M Wu
Jul 12, 2008·The Journal of Physiology·Jonathan B Demb
Jul 20, 2011·The Journal of Physiology·Reza FarajianStewart A Bloomfield
Sep 14, 2014·The Journal of Physiology·Benjamin K StaffordJonathan B Demb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.