PMID: 9547115Apr 18, 1998Paper

Disinhibition syndromes, secondary mania and bipolar disorder in old age

Journal of Affective Disorders
K I Shulman

Abstract

The neurological literature concerning disinhibition syndromes and secondary mania has run in parallel to clinical reports of bipolar disorder in old age. A critical review was conducted of both the neurological and geriatric psychiatry literature in an attempt to integrate the two streams. Disinhibition syndromes include lateralization to the right hemisphere and localization of lesions to the orbito-frontal and basotemporal cortex involving limbic and frontal connections (orbito-frontal circuit). Mania in old age is associated with late onset, heterogeneous neurological disorders and poor outcome. Bipolar disorders in old age may be understood in the context of affective vulnerability influenced by a specific neurobiologic substrate. The clinical literature consists predominantly of small case series and anecdotal reports. Improved understanding of these syndromes may elucidate the pathogenesis and etiology of bipolar disorders and the neuropsychiatric syndromes affecting mood, motivation and behavioural disinhibition.

References

Jan 1, 1976·Brain, Behavior and Evolution·A Kling, H D Steklis
Mar 1, 1992·The American Journal of Psychiatry·K I ShulmanD Kalunian
Jan 1, 1992·Psychosomatics·D Ramchandani, S Riggio
Jan 1, 1992·Postgraduate Medical Journal·E UrG M Besser
Jul 1, 1992·The American Journal of Psychiatry·R C Young, G L Klerman
Nov 1, 1991·Stroke; a Journal of Cerebral Circulation·S KobayashiK Yamashita
Nov 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·S LeeC N Chen
Aug 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·L J Isles, M W Orrell
Dec 1, 1991·Hospital & Community Psychiatry·M MarkA Elizur
Dec 1, 1991·Psychiatry Research·W M McDonaldD G Blazer
Jan 15, 1991·Biological Psychiatry·S E StarksteinR G Robinson
Apr 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·J Snowdon
Jan 1, 1990·The Journal of Neuropsychiatry and Clinical Neurosciences·R A Sweet
Jan 1, 1990·Journal of Psychiatric Research·A KumarR P Friedland
Jun 1, 1990·Annals of Neurology·S E StarksteinR G Robinson
Aug 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·K Stone
Mar 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·D NearyP Goulding
Feb 1, 1988·The Journal of Nervous and Mental Disease·S E StarksteinR G Robinson
Feb 1, 1988·The American Journal of Psychiatry·R G RobinsonT R Price
Oct 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·L N Yatham
Jan 1, 1987·The American Journal of Psychiatry·S ShuklaM G Miller
Jul 1, 1985·The Journal of Nervous and Mental Disease·D B Greenberg, G L Brown
Nov 1, 1973·The British Journal of Psychiatry : the Journal of Mental Science·C C SpicerE Slater
May 1, 1972·The British Journal of Psychiatry : the Journal of Mental Science·J MendlewiczJ L Fleiss
Sep 1, 1984·The American Journal of Psychiatry·J L Cummings, M F Mendez
Sep 1, 1983·The American Journal of Psychiatry·V C Jampala, R Abrams
Jan 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·K Shulman, F Post
Jan 1, 1994·International Journal of Psychiatry in Medicine·S M StrakowskiS A West
Jun 1, 1995·Stroke; a Journal of Cerebral Circulation·T FujikawaY Touhouda
Jul 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·S E StarksteinR Leiguarda
Jan 1, 1994·The American Journal of Psychiatry·M TohenA Satlin
Jan 1, 1993·The Journal of Neuropsychiatry and Clinical Neurosciences·R MigliorelliR G Robinson
Nov 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·G TureckiJ A Del Porto
Aug 1, 1993·Archives of Neurology·J L Cummings
Feb 1, 1993·The American Journal of Psychiatry·C G LyketsosG J Treisman
Mar 1, 1993·Psychosomatics·K A Porter, S H Rosenthal
Jun 1, 1993·The American Journal of Psychiatry·R E JorgeF H Geisler
Dec 15, 1995·Biological Psychiatry·B T WoodsS S Pillay
Oct 1, 1996·The Australian and New Zealand Journal of Psychiatry·C Y LiuH C Liu
Feb 1, 1997·The Journal of Nervous and Mental Disease·S E Starkstein, R G Robinson
Mar 1, 1997·The Psychiatric Clinics of North America·R C Young

❮ Previous
Next ❯

Citations

Aug 19, 2011·Current Psychiatry Reports·Ramsey D'SouzaBruce G Pollock
Nov 30, 2000·Current Treatment Options in Neurology·C D Schneck, R D Buzan
Aug 17, 2002·Biological Psychiatry·George S AlexopoulosDavid W Oslin
Apr 18, 2002·Neurobiology of Aging·Kenneth G Pugh, Lewis A Lipsitz
Dec 12, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H BokuraS Kobayashi
Jul 5, 2001·Acta Psychiatrica Scandinavica·J Nath, R Sagar
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·H GaravanE A Stein
Oct 27, 2004·The Journal of Nervous and Mental Disease·Colin A DeppDilip V Jeste
Jan 13, 2012·Science Translational Medicine·Jennifer M MitchellHoward L Fields
Oct 2, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ye TuBuwei Yu
Jun 2, 2012·Psychosomatics·Anthony R CarlinoDeborah R Kim
Jan 31, 2012·Neurologic Clinics·Nadejda AlekseevaAlireza Minagar
Sep 24, 2004·Bipolar Disorders·Colin A Depp, Dilip V Jeste
Oct 8, 2008·Bipolar Disorders·Laszlo Gyulai, Robert C Young
May 10, 2008·Human Brain Mapping·Koji MatsuoJair C Soares
Aug 8, 2013·Bipolar Disorders·Annemiek DolsMax L Stek
Aug 27, 2005·The Psychiatric Clinics of North America·Martin Adam Goldstein, Michael E Silverman
Nov 30, 2004·General Hospital Psychiatry·Thomas W Heinrich, Jeffrey T Junig
Oct 7, 2017·Journal of Alzheimer's Disease : JAD·Welmoed A KrudopYolande A L Pijnenburg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

© 2022 Meta ULC. All rights reserved