Dismantling, personalising and optimising internet cognitive-behavioural therapy for depression: a study protocol for individual participant data component network meta-analysis

BMJ Open
Toshi A FurukawaOrestis Efthimiou

Abstract

Psychotherapy is a complex intervention, consisting of various components and being implemented flexibly in consideration of individual patient's characteristics. It is then of utmost importance to know which of the various components or combinations thereof are more efficacious, what their specific effect sizes are and which types of patients may benefit more from different components or their combinations. Internet-delivered cognitive-behavioural therapy (iCBT) offers a unique opportunity to systematically review and quantitatively disentangle the efficacy of various components because, unlike face-to-face cognitive-behavioural therapy, it allows identification of constituent components that are actually delivered to patients. We will systematically identify all randomised controlled trials that compared any form of iCBT against another form or a control intervention in the acute phase treatment of adult depression. We will apply component network meta-analysis (cNMA) to dismantle efficacy of individual components. We will use individual participant data in the cNMA to identify participant-level prognostic factors and effect modifiers for different components. The investigators of the primary trials will have obtained ethical...Continue Reading

Citations

Jan 7, 2021·Evidence-based Mental Health·Masatsugu SakataToshi A Furukawa
Mar 19, 2021·Internet Interventions : the Application of Information Technology in Mental and Behavioural Health·Matthias DomhardtHarald Baumeister
Apr 6, 2021·Frontiers in Psychology·Matthias DomhardtHarald Baumeister
May 25, 2021·European Journal of Psychotraumatology·Lena SteublMatthias Domhardt
Sep 1, 2021·Journal of Evidence-based Medicine·Jinhui TianFujian Song
Dec 31, 2021·Current Opinion in Psychiatry·Tanvi Lakhtakia, John Torous

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

IPD
glmnet
OpenBUGS
R
cNMA
iCBT

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