PMID: 11917166Mar 28, 2002Paper

Dismantling the germinal center: comparing the processes of transformation, regression, and fragmentation of the lymphoid follicle

Advances in Anatomic Pathology
Dan Jones

Abstract

The pathologic and immunologic features of the formation of the germinal center have been extensively studied. The process of dissolution of the germinal center is not as well understood. Different patterns of germinal-center breakdown are commonly encountered in diagnostic lymph node biopsy specimens and frequently present difficulties in diagnosis. The current immunologic understanding of germinal-center dynamics is reviewed and correlated with the histologic and immunophenotypic features of three broad classes of germinal center dissolution, namely progressive transformation, regression, and follicle fragmentation. The author suggests that these different patterns represent alternate responses to antigenic stimulation. The relationships of progressive transformation to Hodgkin's disease and of follicular regression to Castleman's disease are discussed.

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Citations

Apr 7, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yasuharu SatoTadashi Yoshino
Dec 28, 2002·The American Journal of Surgical Pathology·Hesham M AminDan Jones
Jan 22, 2013·Human Pathology·Sherif A RezkLawrence M Weiss
Jul 7, 2009·Hematology/oncology Clinics of North America·David J Good, Randy D Gascoyne
Apr 3, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sam KalungiLeif Bostad
Sep 15, 2012·Pediatric Blood & Cancer·Rodney R Miles, Mitchell S Cairo
Feb 27, 2015·Auris, Nasus, Larynx·Nobuhiko SekiTetsuo Himi
Nov 5, 2003·The Journal of Pathology·Kong-Chao ChangDan Jones
Dec 28, 2012·Journal of Clinical and Experimental Hematopathology : JCEH·Yuko KanekoNobuhide Masawa
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geng-Xian ShiJohn H Kehrl

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Castleman disease is a rare disorder that involves an overgrowth of cells in the lymph nodes. Unicentric Castleman disease affects one lymph node, usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes, commonly located in the neck, collarbone, underarm and groin areas. Discover the latest research on Castleman disease here.