Disodium chlodronate prevents bone resorption in experimental periodontitis in rats

Journal of Periodontology
Veruska B M AlencarRonaldo Albuquerque Ribeiro

Abstract

Periodontitis is a chronic disease characterized by alveolar bone loss and inflammatory changes. We studied the effect of disodium chlodronate (CD), a bisphosphonate used in metastatic and metabolic bone disease as a bone resorbing drug, in an experimental periodontitis model (EPD) focusing on anti-resorptive and anti-inflammatory parameters. A nylon thread ligature was placed around the left maxillary molars of 72 male Wistar rats who were sacrificed after 7 or 11 days. Groups were treated daily with CD (1, 5, or 25 mg/kg/sc) starting at day 0 until day 7 (prophylactic CD) or from day 5 until day 11 (curative CD) after periodontitis induction. Non-treated group (NT) consisted of rats subjected to periodontitis that received no pharmacological treatment. Alveolar bone loss (ABL) was measured as the distance between the cuspid tips and the alveolar bone. The right jaw was used as control. The hemiarcades were processed for histopathologic analysis. In NT group there was significant ABL, severe mononuclear cells influx, and increase in osteoclast numbers. Prophylactic CD treatment decreased the ABL 25.8%, 61.6%, and 75.5% as compared to NT for the 1, 5, and 25 mg/kg CD doses, respectively. Curative CD treatment decreased the ABL ...Continue Reading

References

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Citations

Jan 5, 2011·International Journal of Evidence-based Healthcare·Emma MegsonP Mark Bartold
Nov 9, 2005·Journal of Periodontology·Adriana M A MenezesGerly Anne C Brito
Apr 4, 2006·Journal of Periodontology·Juan A GoyaPatricia M Mandalunis
Feb 8, 2014·Journal of Periodontology·Flávia A C FurlanetoMichel R Messora
Mar 10, 2016·Clinical Oral Investigations·Carmen L Mueller StorrerGiuseppe Alexandre Romito
Sep 1, 2005·Journal of Clinical Periodontology·Giovanni E Salvi, Niklaus P Lang
Jan 10, 2006·Periodontology 2000·Alpdogan KantarciThomas E Van Dyke
Jun 13, 2015·Journal of Periodontology·Juliano De AlmeidaValdir Gouveia Garcia
Oct 24, 2018·Microscopy Research and Technique·Rafael Scaf de MolonJoni Augusto Cirelli
Nov 24, 2005·Journal of Periodontal Research·J A GaratA M Ubios
Sep 22, 2019·International Journal of Molecular Sciences·Rafael Scaf de MolonMarije I Koenders
May 3, 2012·American Journal of Therapeutics·Tommaso IannittiBeniamino Palmieri
Sep 16, 2017·Journal of Periodontology·Nara L T NunesFlávia A C Furlaneto
Nov 25, 2003·Journal of Periodontal Research·D EkuniT Watanabe

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