PMID: 7036817Mar 1, 1982Paper

Disopyramide

Annals of Internal Medicine
F MoradyJ Desai

Abstract

Since disopyramide was introduced 5 years ago, the therapeutic spectrum of this drug in treating patients with ventricular and atrial arrhythmias has been found to be similar to that of the other type I antiarrhythmic drugs, quinidine and procainamide. Disopyramide has the potential to suppress sinus node function and, therefore, must be used cautiously in patients with the sick sinus syndrome. The available data indicate that it can be used safely in patients with bundle branch block and first-degree or type I second-degree atrioventricular block. Disopyramide has been found at times to precipitate ventricular tachycardia or ventricular fibrillation. Because this drug often causes decompensation in patients with congestive heart failure, it must be used very cautiously, if at all, in such patients.

Citations

Jan 1, 1989·DICP : the Annals of Pharmacotherapy·A J EllsworthJ L Bell
Jul 1, 1997·Clinical Cardiology·L L Mackstaller, J S Alpert
Jun 5, 2016·Journal of Cardiovascular Pharmacology and Therapeutics·Jonathan W Waks, Peter Zimetbaum
Apr 1, 1988·Journal of Clinical Pharmacology·E V CapparelliM S Chow
Dec 20, 2015·Pharmacotherapy·Nathan J Verlinden, James C Coons
Jan 1, 1989·Fundamental & Clinical Pharmacology·P CacoubC Jacobs

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