PMID: 25772156Mar 17, 2015Paper

Disorder in milk proteins: structure, functional disorder, and biocidal potentials of lactoperoxidase

Current Protein & Peptide Science
Hussein A AlmehdarElrashdy M Redwan

Abstract

This article continues a series of reviews on the abundance and roles of intrinsic disorder in milk proteins. Besides caseins, which are the major proteinaceous constituents of any milk that can be isolated by isoelectric precipitation, milk contains a set of soluble whey proteins, such as β-lactoglobulin, α-lactalbumin, serum albumin, immunoglobulins, lactoferrin, lactoperoxidase, glycomacropeptide, and proteose peptone (the last two are soluble casein derivatives). Lactoferrin and lactoperoxidase (LPO) are known to possess prominent biocidal activity, serving as efficient antibiotics and antiviral agents against a wide spectrum of bacteria, fungi, and viruses. LPO is a heme-containing peroxidase expressed as preproprotein. The mature protein has a single catalytic domain, structure of which is known for a protein isolated from several species. Functionally, LPO is a crucial component of the LPO system that includes LPO, hydrogen peroxide (H2O2), and thiocyanate (SCN(-)), being a well-studied, naturally occurring antimicrobial system in milk that is effective against many microorganisms and some viruses. Although various aspects of LPO structure and function are rather well studied and were subjects of several recent reviews, ...Continue Reading

Citations

Jun 19, 2015·International Journal of Molecular Sciences·Aidan PetrovichBin Xue
Nov 18, 2016·Applied Biochemistry and Biotechnology·Esmail M El-FakharanyElrashdy M Redwan
Feb 7, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elrashdy M RedwanVladimir N Uversky
Nov 23, 2017·Pediatric Research·Monika CieslakJaques Belik
Mar 22, 2019·Journal of Biomolecular Structure & Dynamics·Elrashdy M RedwanVladimir N Uversky
Jan 27, 2019·Current Protein & Peptide Science·Fengtao MaPeng Sun
Feb 29, 2020·Food & Function·Dereck E W ChattertonPer T Sangild
Jul 23, 2015·Applied Microbiology and Biotechnology·Tzi Bun NgJiang Xia
Apr 18, 2017·Experimental and Therapeutic Medicine·Esmail Mohamad El-FakharanyElrashdy Moustafa Redwan
Nov 28, 2020·Preparative Biochemistry & Biotechnology·Esmail M El-Fakharany

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