Disorder, not just state of risk: meta-analysis of functioning and quality of life in people at high risk of psychosis

The British Journal of Psychiatry : the Journal of Mental Science
Paolo Fusar-PoliPhilip McGuire

Abstract

The nosology of the psychosis high-risk state is controversial. Traditionally conceived as an 'at risk' state for the development of psychotic disorders, it is also conceptualised as a clinical syndrome associated with functional impairment. To investigate meta-analytically the functional status of patients at high clinical risk for psychosis and its association with longitudinal outcomes. Three meta-analyses compared level of functioning (n = 3012) and quality of life (QoL) (n = 945) between a high-risk group, a healthy control group and group with psychosis, and baseline functioning in people in the high-risk group who did or did not have a transition to psychosis at follow-up (n = 654). People at high risk had a large impairment in functioning (P<0.001) and worse QoL (P = 0.001) than the healthy control group, but only small to moderately better functioning (P = 0.012) and similar QoL (P = 0.958) compared with the psychosis group. Among the high-risk group, those who did not develop psychosis reported better functioning (P = 0.001) than those who did. Our results indicate that the high-risk state is characterised by consistent and large impairments of functioning and reduction in QoL similar to those in other coded psychiatr...Continue Reading

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Citations

Feb 3, 2016·The British Journal of Psychiatry : the Journal of Mental Science·David J Castle
Feb 3, 2016·The British Journal of Psychiatry : the Journal of Mental Science·Matteo RocchettiPaolo Fusar-Poli
Jun 15, 2015·Psychiatry Research·Irina FalkenbergPaolo Fusar-Poli
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Jan 27, 2017·Early Intervention in Psychiatry·Anna ÄrmänenMaija Lindgren
Feb 18, 2017·Current Opinion in Psychiatry·Anita Riecher-Rössler, Erich Studerus
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May 3, 2018·Psychiatry and Clinical Neurosciences·Tsutomu Takahashi, Michio Suzuki
Jun 14, 2018·Early Intervention in Psychiatry·Laelia BenoitMarie R Moro
Aug 10, 2018·Psychology and Psychotherapy·Jakob ScheunemannTania M Lincoln
Oct 23, 2018·JAMA Psychiatry·Paolo Fusar-PoliEwout W Steyerberg
Oct 23, 2018·JAMA Psychiatry·Paolo Fusar-PoliIlaria Bonoldi
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