PMID: 8605225Feb 9, 1996Paper

Disordered expression of hepatic glycolytic and gluconeogenic enzymes in Otsuka Long-Evans Tokushima fatty rats with spontanteous long-term hyperglycemia

Biochimica Et Biophysica Acta
K HottaY Matsuzawa

Abstract

Expression of key regulatory enzymes involved in glucose metabolism was studied in the livers of Otsuka Long-Evans Tokushima fatty (OLETF) rats, a model of non-insulin dependent diabetes mellitus. The activity and mRNA levels of glucokinase and L-type pyruvate kinase was increased in the liver of OLETF rats compared with control rats. There was no such remarkable change in liver-type phosphofructokinase. The activities of glucose-6-phosphatase and fructose-1,6-biphosphatase also increase despite high plasma levels of glucose and insulin. The activity of phosphoenolpyruvate carboxykinase did not show any significant change. The mRNA levels for fructose-1,6-biphosphatase, and phosphoenolpyruvate carboxykinase exhibited no marked changes. These results suggest that the expression of glucose-6-phosphatase and fructose-1,6-biphosphatase is disordered in OLETF rats.

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Citations

Nov 10, 2012·Archives of Pharmacal Research·Chun XiaoJu-Mei Zhang
Jan 4, 2001·Diabetes Research and Clinical Practice·J NakamuraN Hotta
May 13, 2004·American Journal of Physiology. Endocrinology and Metabolism·Yuka FujimotoMasakazu Shiota
Mar 20, 1998·The Journal of Clinical Endocrinology and Metabolism·I YoshiuchiY Matsuzawa

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