Disorders of interstitial cells of Cajal

Journal of Pediatric Gastroenterology and Nutrition
Alan J Burns

Abstract

Interstitial cells of Cajal (ICCs) have, in the past 2 decades, been recognised as important elements in the regulation of gastrointestinal motility. Specifically, they have been shown to be critical for the generation and propagation of electrical slow waves that regulate the phasic contractile activity of gastrointestinal smooth muscle, and for mediating neurotransmission from enteric motor neurons to smooth muscle cells. These different functional roles are carried out by different phenotypic classes of ICC that have discrete distributions within the tunica muscularis. Identifying the functional roles of ICC within the gut has been facilitated by studying mutant mice deficient in ICC, either as a consequence of loss of the tyrosine kinase receptor, Kit, or its ligand, stem cell factor, both of which are necessary for normal ICC development. In humans, under certain pathophysiological conditions, loss or defects in ICC networks appear to play a role in the generation of certain motility disorders. Alterations in ICC distribution have been reported in conditions such as achalasia, chronic intestinal pseudoobstruction, Hirschsprung disease, inflammatory bowel diseases, and slow transit constipation. Molecular and genetic techni...Continue Reading

References

Dec 1, 1995·The American Journal of Physiology·S M WardK M Sanders
Oct 1, 1996·Gastroenterology·J M VanderwindenJ J Vanderhaeghen
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·A J BurnsS M Ward
Nov 25, 1996·Developmental Biology·H M YoungD F Newgreen
Aug 29, 1998·Journal of Pediatric Surgery·M HorisawaS Torihashi
Oct 16, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K M SandersS M Ward
Dec 22, 1999·Microscopy Research and Technique·J M Vanderwinden, J J Rumessen
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sean M WardKenton M Sanders
Dec 13, 2003·International Review of Cytology·Jüri J Rumessen, Jean-Marie Vanderwinden
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S M WardG D S Hirst
Apr 6, 2006·Cell and Tissue Research·Maria-Simonetta Faussone-PellegriniMenachem Hanani

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Citations

Jan 10, 2009·World Journal of Gastroenterology : WJG·Dong-Hua LiaoHans Gregersen
Jun 27, 2013·World Journal of Gastroenterology : WJG·Jie ChenWei Cai
Mar 17, 2016·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Mariana Tresoldi das Neves RomaneliElizete Aparecida Lomazi
Sep 14, 2014·The Journal of Physiology·Yoshihiko KitoKenton M Sanders
Oct 6, 2010·The Journal of Physiology·Kenton M SandersSean M Ward
Oct 30, 2015·Pediatric Surgery International·David CoylePrem Puri
Jul 14, 2010·Journal of Pediatric Surgery·Tadao OkadaSatoru Todo
Mar 15, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ons AzzabiAhmed Maherzi
Jul 19, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P J BlairS M Ward
Jan 12, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G W HennigK M Sanders
Jul 19, 2016·Canadian Journal of Physiology and Pharmacology·Ivan VargaStefan Polak
Jul 3, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Donghua LiaoHans Gregersen
Jan 28, 2010·Journal of Forensic Sciences·Steven J Rubenzer, Scott B Stevenson
May 27, 2010·Clinical and Experimental Dermatology·M FunabikiY Miyachi
Sep 12, 2012·Nature Reviews. Gastroenterology & Hepatology·Kenton M SandersSean M Ward
Jul 6, 2014·Physiological Reviews·Kenton M SandersSang Don Koh
Jul 6, 2015·Current Gastroenterology Reports·Shamaila H WaseemJoseph M Croffie
Dec 22, 2017·Signal Transduction and Targeted Therapy·Xudong ZhuQinsong Sheng
Sep 18, 2020·Journal of Indian Association of Pediatric Surgeons·Tanmay PandePrateek Kinra
Sep 12, 2018·Scientific Reports·Masae KobayashiJames C Y Dunn
Sep 24, 2020·Gastroenterology Research and Practice·Mark A FlemingDaniel E Levin

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