Disorders of lymph flow

Academic Radiology
C L Witte, M H Witte

Abstract

Disturbances in blood capillary exchange of fluid, macromolecules, and cells across intact and abnormal microvessels and deranged lymphatic transport are integral, interacting components in disorders of tissue swelling. Lymphedema or low-output failure of the lymph circulation is often indolent for many years before lymphatic insufficiency (failure) and tissue swelling emerge and persist. Superimposed occult or overt infection (lymphangitis) are probably major contributors to progressive limb deformity (elephantiasis). Long-standing lymphedema is characterized by trapping in the skin and subcutaneous tissue of fluid, extravasated plasma proteins, and other macromolecules: impaired immune cell trafficking; abnormal processing of autologous and foreign antigens; heightened susceptibility to superimposed infection; local immunodysregulation; defective lymphatic (lymphangion) propulsion from an imbalance of mediators regulating vasomotion; soft-tissue overgrowth; scarring and hypertrophy; and exuberant angiogenesis occasionally culminating in vascular tumors (Fig. 8). In contrast to the blood circulation, where flow depends primarily on the propulsive force of the myocardium, lymph propulsion depends predominately on intrinsic trun...Continue Reading

References

Jul 18, 1978·Pflügers Archiv : European journal of physiology·T OhhashiT Azuma
May 1, 1977·Vascular Surgery·C L WitteA E Dumont
Mar 1, 1978·Annals of Plastic Surgery·T A Miller
Oct 1, 1976·The Journal of Physiology·N G McHale, I C Roddie
Jan 1, 1992·Magnetic Resonance Imaging·T C CaseW H Williams
Oct 1, 1992·AJR. American Journal of Roentgenology·T TanouraA Green
Apr 1, 1992·Investigative Radiology·T C CaseR Crandall
Jun 1, 1989·Annals of Plastic Surgery·E FöldiL Clodius
Dec 1, 1986·World Journal of Surgery·N L Browse
Mar 1, 1973·The Journal of Physiology·H J Mawhinney, I C Roddie
Feb 1, 1969·Annals of Internal Medicine·M H WitteK Kintner
Sep 1, 1965·The Journal of Physiology·J G HallG Woolley
May 1, 1966·The American Journal of Anatomy·L V Leak, J F Burke
Dec 1, 1981·Circulation·A BollingerJ Seglias
Apr 1, 1984·The British Journal of Dermatology·H PartschB Wenzel-Hora
Sep 24, 1981·Nature·M G Johnston, J L Gordon
Dec 1, 1980·The Journal of Physiology·N G McHaleK D Thornbury
Feb 1, 1995·Radiology·H I MolitchE vanSonnenberg
Oct 14, 1993·The New England Journal of Medicine·J R Casley-SmithN B Piller
May 17, 1958·British Medical Journal·G W TAYLORW G DANGERFIELD
Jan 1, 1963·Physiological Reviews·R W BRAUER
Jan 1, 1968·The Journal of Cell Biology·L V Leak, J F Burke

❮ Previous
Next ❯

Citations

Nov 2, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Hiroshi FurukawaTsuneki Sugihara
Oct 16, 2007·Lymphatic Research and Biology·Lisa M HodgeH Fred Downey
Dec 25, 2013·Lymphatic Research and Biology·Artur SchanderLisa M Hodge
Sep 13, 2013·Lymphatic Research and Biology·Shan Liao, Timothy P Padera
Sep 11, 2008·British Journal of Anaesthesia·N Soni, P Williams
Jan 25, 2003·Annals of the New York Academy of Sciences·Lee V LeakLance A Liotta
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·J L FaulT A Raffin
Jun 22, 2011·Advanced Drug Delivery Reviews·Jaime A YáñezKevin B Alton
Dec 5, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Cristina T KeslerTimothy P Padera
Aug 15, 2014·The British Journal of Surgery·M MiharaN Murai
Oct 30, 2016·The American Journal of Pathology·Patrick MuckaDiane R Bielenberg
Mar 24, 2004·Integrative Cancer Therapies·C Murray Ardies
Dec 22, 2004·Lymphatic Research and Biology·Kala K DavisJohn L Faul
Oct 26, 2018·Circulation Research·Jorge A Castorena-GonzalezMichael J Davis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

AIDS Malignancies (ASM)

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.